Susumu Nakano

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The existence of circadian variations of apomorphine-induced stereotypy was determined. Male Wistar rats, standardized to a light-dark cycle (lights on from 7:00--19:00) for three weeks, were injected with apomorphine hydrochloride (1 mg/kg or 3 mg/kg) at one of six times (9:00, 13:00, 17:00, 21:00, 1:00 and 5:00). A significant time-of-day effect was found(More)
Volunteer subjects were used to compare a potential antianxiety drug (nabilone, 2-mg single doses) with a standard drug (diazepam, 5-mg single doses). A double-masked design with placebo control was used. Volunteer subjects were selected on the basis of high levels of train anxiety and were tested by two anxiety-inducing procedures--the mirror drawing test(More)
The beta-adrenergic receptor-blocking drug, d,l-propranolol, was compared with placebo for relief of experimentally induced anxiety. Subjects were chosen on the basis of having high levels of trait anxiety. Stress was induced experimentally by two performance tests. Single 40-mg doses of propranolol significantly slowed the heart rate, suggesting a(More)
The subjects were 24 healthy males, 19 to 21 yr old. Twelve subjects had high neuroticism (HN) levels determined by Maudsley Personality Inventory, and 12 had low neuroticism (LN) levels. Subjects took a single 5-mg dose of diazepam (DZP) after a standardized breakfast. The mean plasma concentration for DZP was significantly higher in HN subjects at 1.5 hr(More)
OBJECTIVE Spinal cord stimulation (SCS) is expected to have analgesic effects in patients with neuropathic pain, ischemic pain, or mixed pain. The type of leg pain caused by lumbar spinal stenosis (LSS) is considered as mixed pain, which is expected to respond to SCS. However, there is no established view on the usefulness of SCS in the management of this(More)
Pain is a private internal event, the degree of which can not be evaluated directly by others. The measurement of the nociceptive pain threshold may apply to the evaluation of the degree of the pain. The instruments using mechanical and electrical stimulation are available for the clinical application. Thermotest allows the testing of quantitative(More)
Mass fragmentography was used for quantitation of apomorphine in whole rat brain. Following extraction with 0.45 N perchloric acid, the components were derivatized to the O,O-bis(trimethylsilyl) (TMS) derivatives with N,O-bis(trimethylsilyl)trifluoroacetamide at 30 degrees C. The molecular ions of the TMS derivatives of apomorphine (m/z 411) and(More)
Relationships between aging effects on apomorphine (AP)-induced stereotypy and AP concentrations in plasma and brain were studied in rats. In two separate behavioral studies, four groups of male Wistar rats (3, 6, 20, and 43 weeks of age) and two groups of female Wistar rats (5 and 35 weeks of age) were used, respectively: The former groups were(More)