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- Publications
- Influence
Syntheses, X-ray crystal structures, DNA binding, oxidative cleavage activities and antimicrobial studies of two Cu(II) hydrazone complexes
- S. Banerjee, Susmita Mondal, +6 authors S. Mitra
- Chemistry
- 2 September 2009
Abstract From a mononuclear Cu(II)-hydrazone complex [Cu(PBH)2] (1), one μ1,1-azido bridged dinuclear Cu(II) complex having the formula [{Cu(PBH)(μ1,1-NNN)}2] (2) (where HPBH =… Expand
Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38…
- Susmita Mondal, C. Mandal, R. Sangwan, S. Chandra, C. Mandal
- Biology, Medicine
- Molecular Cancer
- 13 September 2010
BackgroundCeramide is an important second messenger that has diverse cellular and biological effect. It is a specific and potent inducer of apoptosis and suppressor of cell growth. In leukemia,… Expand
Natural products: promising resources for cancer drug discovery.
- Susmita Mondal, S. Bandyopadhyay, Mrinal K Ghosh, S. Mukhopadhyay, Siddhartha Roy, C. Mandal
- Biology, Medicine
- Anti-cancer agents in medicinal chemistry
- 2012
Natural products are important sources of anti-cancer lead molecules. Many successful anti-cancer drugs are natural products or their analogues. Many more are under clinical trials. The present… Expand
PG545 enhances anti-cancer activity of chemotherapy in ovarian models and increases surrogate biomarkers such as VEGF in preclinical and clinical plasma samples.
- B. Winterhoff, L. Freyer, +13 authors V. Shridhar
- Medicine
- European journal of cancer
- 1 May 2015
BACKGROUND
Despite the utility of antiangiogenic drugs in ovarian cancer, efficacy remains limited due to resistance linked to alternate angiogenic pathways and metastasis. Therefore, we investigated… Expand
Quinacrine promotes autophagic cell death and chemosensitivity in ovarian cancer and attenuates tumor growth
- Ashwani Khurana, Debarshi Roy, +5 authors V. Shridhar
- Medicine
- Oncotarget
- 16 October 2015
A promising new strategy for cancer therapy is to target the autophagic pathway. In the current study, we demonstrate that the antimalarial drug Quinacrine (QC) reduces cell viability and promotes… Expand
9-O-acetylated GD3 triggers programmed cell death in mature erythrocytes.
- Kankana Mukherjee, S. Chowdhury, +4 authors C. Mandal
- Biology, Medicine
- Biochemical and biophysical research…
- 26 October 2007
An acetylated modification of a tumor-associated ganglioside GD3 (9-O-AcGD3) is expressed in certain tumors and present during early stages of development in different tissues. However, the status… Expand
Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers
- Susmita Mondal, Debarshi Roy, +14 authors V. Shridhar
- Chemistry, Medicine
- International journal of cancer
- 30 October 2018
Metabolic alterations are increasingly recognized as important novel anti‐cancer targets. Among several regulators of metabolic alterations, fructose 2,6 bisphosphate (F2,6BP) is a critical… Expand
Quinacrine in endometrial cancer: Repurposing an old antimalarial drug.
- E. Kalogera, Debarshi Roy, +5 authors V. Shridhar
- Medicine
- Gynecologic oncology
- 1 July 2017
OBJECTIVE
Generate preclinical data on the effect of quinacrine (QC) in inhibiting tumorigenesis in endometrial cancer (EC) in vitro and explore its role as an adjunct to standard chemotherapy in an… Expand
Nutritional stress reprograms dedifferention in glioblastoma multiforme driven by PTEN/Wnt/Hedgehog axis: a stochastic model of cancer stem cells
- Susmita Mondal, Kaushik Bhattacharya, C. Mandal
- Biology, Medicine
- Cell Death Discovery
- 1 December 2018
The emergence and maintenance of cancer stem-like cells (CSCs) are usually governed by tumor niche. Tumor niche always provides metabolic challenges to cancer cells and CSCs mostly because of tissue… Expand
Switching the regioselectivity in the copper-catalyzed synthesis of iodoimidazo[1,2-a]pyridines.
- Sadhanendu Samanta, S. Jana, Susmita Mondal, K. Monir, Swapan K. Chandra, A. Hajra
- Chemistry, Medicine
- Organic & biomolecular chemistry
- 31 May 2016
A unique copper-catalyzed binucleophilic switching of 2-aminopyridine has been developed for the regioselective synthesis of 2- and 3-iodoimidazo[1,2-a]pyridines using alkenes/alkynes as coupling… Expand
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