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Creutzfeldt-Jakob disease (CJD) has been considered infectious since the mid-1960s, but its transmissibility through the transfusion of blood or blood products is controversial. The causative agent's novel undefined nature and resistance to standard decontamination, the absence of a screening test, and the recognition that even rare cases of transmission(More)
INTRODUCTION A descriptive epidemiological analysis to update trends of Creutzfeldt-Jakob disease (CJD) deaths, from 1979-2001, was undertaken. METHODS Cases with CJD as underlying cause were extracted. Age-adjusted death rates by age, sex, and province were calculated. Information on birthplace, autopsy indications and type of work were examined for(More)
A descriptive analysis of hepatocellular carcinoma (HCC) deaths in Canada for 1995 was undertaken. Cases (ICD-9 155.0) were identified from the Statistics Canada annual mortality file; age-adjusted death rates by age, sex and province were calculated. Antecedent causes and conditions leading to death listed on the death certificate, including viral(More)
BACKGROUND AND METHODS To provide information on poorly described Canadian hepatocellular cancer epidemiology, we analyzed incident cases abstracted from the Canadian Cancer Registration Database (1969-1997) and Canadian annual death data (1969-1998). Age, sex, geographic distribution, and secular trends were described. Projection models were developed for(More)
There is a high level of uncertainty surrounding the potential for iatrogenic prion transmission through transplantation, medical instrument reuse, blood transfusion, and blood product use due to a lack of evidence-based research on this important risk issue. A group of specialists was enlisted to evaluate some of the knowledge gaps in this area using the(More)
Using expert judgment data from the TU Delft's expert judgment data base, we compare the performance of different weighting schemes, namely equal weighting, performance based weighting from the classical model (Cooke, 1991), social network weighting and likelihood weighting. The picture that emerges with regard to social network weights is rather mixed. SN(More)
BACKGROUND When comparing transfused versus nontransfused patients, erythrocyte transfusion is consistently associated with increased mortality. Nonetheless, unmeasured confounding may unduly influence this comparison. This unmeasured risk may have less influence on comparisons of patients undergoing surgery at hospitals with differing transfusion rates. (More)
We propose a mathematical model describing the dynamics of hepatitis B or C virus infection. The method of characteristics reduces the age-structured model to a system of differential equations with distributed delay. The model is rigorously analyzed, and a detailed stability analysis is performed. The model, consisting of two mutually exclusive(More)
BACKGROUND Current practice in transfusion medicine promotes clear documentation of transfusion-related events including the fact that the patient has been informed of the related risks and benefits. STUDY DESIGN AND METHODS A retrospective review of 1005 patient charts was carried out to determine documentation. RESULTS Most patients were from general(More)