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OBJECTIVES To develop a population specific pharmacogenetic acenocoumarol dosing algorithm for north Indian patients and show its efficiency in dosage prediction. METHODS Multiple and linear stepwise regression analyses were used to include age, sex, height, weight, body surface area, smoking status, VKORC1 -1639 G>A, CYP4F2 1347 G>A, CYP2C9*2,*3 and GGCX(More)
BACKGROUND Cerium oxide nanoparticles (nanoceria) are effective at quenching reactive oxygen species (ROS) in cell culture and animal models. Although nanoceria reportedly deposit in lungs, their efficacy in conferring lung protection during oxidative stress remains unexplored. Thus, the study evaluated the protective efficacy of nanoceria in rat lung(More)
A program using a strategy of donating a single automatic external defibrillator to 35 schools in the Boston area resulted in compliance with American Heart Association guidelines on automatic external defibrillator placement and training and 2 successful resuscitations from sudden cardiac arrest. Participating schools indicated a high degree of(More)
AIM OF THE STUDY To evaluate the antidiabetic and antioxidant effects of various fractions of Phyllanthus simplex on alloxan induced diabetes in rats. MATERIALS AND METHODS Hypoglycemic effect of Phyllanthus simplex fractions was evaluated in normal and diabetic rats. Diabetes was induced by intraperitoneal injection of alloxan monohydrate (120 mg/kg).(More)
Over the past decade, syncope has become increasingly recognized as an indicator of poor prognosis in patients with nonischemic dilated cardiomyopathy (NIDCM). In several clinical series, patients with depressed ejection fraction in the absence of significant obstructive coronary artery disease who experience syncope have been shown to be at high risk for(More)
AIM OF THE STUDY Marsilea minuta Linn. (Marsileaceae) has been referred in Indian traditional medicine system (Ayurveda) for the treatment of insomnia and other mental disorders. Marsiline isolated from Marsilea minuta was reported to have sedative and anticonvulsant property. The ethanol extract of Marsilea minuta was standardised for marsiline (1.15%,(More)
BACKGROUND Numerous tests are available to assess patient risk for bleeding or thrombosis. Appropriate use of these tests must involve consideration of the clinical setting, disease prevalence, performance characteristics of the tests, cost, and consequences of false-positive and false-negative results. PURPOSE To summarize information about coagulation(More)
A successful closure of an aneurysmal aorto-right ventricular tunnel (ARVT) in a 16-year-old male patient is reported here. An attempt at device closure had failed in this patient. Diagnosis was confirmed by Doppler echocardiography, 3-dimensional computed tomography, and cardiac catheterization. Surgical closure with a Dacron patch (W.L. Gore & Associates,(More)
Metallopharmaceuticals play an important role in contemporary society as therapeutic and diagnostic agents. Many metallopharmaceuticals have been developed to treat/cure a variety of cancers. Besides platinum compoundscisplatin, carboplatin, oxaliplatin, tetraplatin, satraplatin etc., non-platinum compounds viz. NAMI-A, KP1019, KP46, auranofin and As2O3(More)