Susheel Sharma

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Neuropathy is often seen in uncontrolled diabetes and the mechanisms involved for neuropathic pain are poorly understood. Hyperglycemia is a consequence of chronic uncontrolled diabetes and it is postulated to produce neuropathic pain. Therefore, in this study, we have investigated the effects of hyperglycemia on Na(+) channel kinetics in cultured dorsal(More)
This paper aims at to develop floating gate MOSFET (FGMOS) based low voltage, voltage-mode and current-mode circuits operating at ± 0.75 V supply voltages. The utility of FGMOS for low voltage applications lies in its threshold voltage tunability. FGMOS based low voltage current mirror and its subsequent use in the development of second-generation current(More)
Current conveyors are unity gain active elements exhibiting high linearity, wide dynamic range and high frequency performance than their voltage mode counterparts. The new current conveyor operating at low-voltage supplies high input impedance and low output impedance and consumes less power. In this study, a new low-voltage class AB second generation(More)
L-PGlu-(2-propyl)-L-His-L-ProNH₂ (NP-647) is a CNS active thyrotropin-releasing hormone (TRH) analog with potential application in various CNS disorders including seizures. In the present study, mechanism of action for protective effect of NP-647 was explored by studying role of NP-647 on epileptiform activity and sodium channels by using patch-clamp(More)
Current mirror (CM) is the basic building block in analog and mixed mode circuit design. For high performance analog circuit applications, the current transfer ratio, output impedance and output swing are the most important parameters to determine the performance of the current mirror. CM's are important for analog integrated circuits because of their wide(More)
Design of log domain low pass filters using quasi floating gate MOSFET " , Abstract—This paper presents the design of low voltage analog filters and highlights its comparison with FGMOS and QFGMOS. Though BJTs offer higher transconductance and high frequency response but do not favor device down scaling and high integration. Therefore CMOS version of(More)
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