Susanne Neubert

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The endosomal sorting complexes required for transport (ESCRT) guides transmembrane proteins to domains that bud away from the cytoplasm. The ESCRT machinery consists of four complexes. ESCRT complexes 0-II are important for cargo recognition and concentration via ubiquitin binding. Most of the membrane bending function is mediated by the large multimeric(More)
The paper describes a specification approach for knowledge-based systems (kbs) combining semiformal and formal specification techniques. The semiformal knowledge representation uses a hypermedia-based formalism which serves as a communication basis between expert and knowledge engineer. This representation is also the basis for the formalization process(More)
Eukaryotic cells comprise a highly dynamic vesicular trafficking system that selects and delivers proteins and lipids to different cellular locations. On the crossroad between endocytosis, secretion and transport to the vacuoles or lysosomes are sorting endosomes and multivesicular bodies (MVBs). 1,2 Membrane proteins dedicated for either lysosomal/vacuolar(More)
IWMI's mission is to improve water and land resources management for food, livelihoods and nature. In serving this mission, IWMI concentrates on the integration of policies, technologies and management systems to achieve workable solutions to real problems—practical, relevant results in the field of irrigation and water and land resources. The publications(More)