Susanne Michaelis

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In eukaryotic cells, most extracellular proteins exit the cell via the classical secretory pathway (ER-->Golgi-->secretory vesicles). A notable exception to this pattern is the Saccharomyces cerevisiae mating pheromone alpha-factor, an isoprenylated, methylated, oligopeptide signaling molecule which uses a distinctly non-classical mechanism for secretion.(More)
The potential of the internet has been recognised to enhance government initiated citizen communication. Despite limited experience so far, some lessons for designing online-participation have been learned: Ensuring the external and internal relevance of online consultation processes seems crucial. Some measurements to ensure the external and internal(More)
Losses of genetic material within human chromosome regions (HCR) 3p12–p14 and 3p21–p22 are observed in various neoplasias, suggesting tumor suppressor gene (TSG) loci within these regions. HCR 3p14 is particularly interesting as it contains the t(3;8) translocation breakpoint of a hereditary renal cell carcinoma, the FRA3B fragile site, and DNA markers(More)
Deletions and translocations of human chromosome region 3p14 are considered to be involved in the development of various human malignancies, suggesting the existence of at least one tumor suppressor gene in human chromosome region 3p14. To analyze this region we constructed a YAC-contig from the distal region of 3p13 to the proximal part of 3p21. The contig(More)
Deletions and translocations of human chromosome region 3p14 are considered to be involved in the development of various human malignancies, suggesting the existence of at least one tumor suppressor gene in human chromosome region 3p14. To analyze this region we constructed a YAC-contig from the distal region of 3p13 to the proximal part of 3p21. The contig(More)
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