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OBJECTIVES Uncontrolled viral replication and antiretroviral treatment (ART) may independently contribute to hepatic mitochondrial toxicity. The present study was designed to explore the longitudinal effects of treatment modifications on hepatic mitochondrial function by means of noninvasive (13) C-methionine breath test (MeBT) diagnostics. METHODS A(More)
OBJECTIVES An increasing proportion of deaths among human immunodeficiency virus (HIV)-infected persons are due to hepatic complications. Hepatitis coinfection, antiretroviral treatment and co-occurrence of metabolic risk factors contribute to hepatic mitochondrial damage manifesting in hepatic steatosis and steatohepatitis. The aim was to assess disease-(More)
BACKGROUND Fertility might be reduced in women with multiple sclerosis (MS), although only few studies exist and the underlying reasons are not well understood. Similar to other autoimmune diseases, a decreased ovarian reserve may contribute to impaired fertility in women with MS. Anti-Müllerian hormone (AMH) is an established marker of the ovarian reserve(More)
OBJECTIVE Little is known about seizures in natalizumab-associated progressive multifocal leukoencephalopathy (NAT-PML). METHODS A review of clinical records of 15 NAT-PML patients with multiple sclerosis (MS) treated at a German university hospital. RESULTS Some 53% (8/15) of our patients developed seizures with often multiple semiologies (seven grand(More)
BACKGROUND AND PURPOSE The aim of this study was to elucidate the role of therapy-related cardiotoxicity in multiple sclerosis (MS) patients treated with mitoxantrone and to identify potential predictors for individual risk assessment. METHODS Within a multicenter retrospective cohort design, cardiac side effects attributed to mitoxantrone were analyzed(More)
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