Susanne Kloeker

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Focal adhesions are specialized regions of the cell surface where integrin receptors and associated proteins link the extracellular matrix to the actin cytoskeleton. To define the cellular role of the focal adhesion protein zyxin, we characterized the phenotype of fibroblasts in which the zyxin gene was deleted by homologous recombination. Zyxin-null(More)
2 SUMMARY TGFβ−1 contributes to tumor invasion and cancer progression by increasing the motility of tumor cells. To identify genes involved in TGFβ-mediated cell migration, the transcriptional profiles of human mammary epithelial cells (HMEC) treated with TGFβ were compared to untreated cells by cDNA microarray analysis. One gene upregulated by TGFβ was(More)
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