Susanne G. Carpenter

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BACKGROUND In the era of breast conservation therapy, preoperative imaging is imperative in planning a single definitive surgical treatment. METHODS We performed a retrospective review of a prospectively collected database of patients treated at a single institution for invasive breast cancer over 5 years. Clinical and pathologic variables were analyzed(More)
Oncolytic viruses show promise for treating cancer. However, to assess therapeutic efficacy and potential toxicity, a noninvasive imaging modality is needed. This study aimed to determine if insertion of the human sodium iodide symporter (hNIS) cDNA as a marker for non-invasive imaging of virotherapy alters the replication and oncolytic capability of a(More)
BACKGROUND The accuracy of magnetic resonance imaging (MRI) in identifying residual disease after breast conservation therapy (BCT) is unclear. METHOD Review of an institutional database identified patients with positive or close (<or=2 mm) margins undergoing MRI before re-excision. Histopathologic correlation was performed. RESULTS Forty-three women(More)
INTRODUCTION Oncolytic viruses show promise for treating cancer. However, to assess therapy and potential toxicity, a noninvasive imaging modality is needed. This study aims to determine the in vivo biodistribution, and imaging and timing characteristics of a vaccinia virus, GLV-1h153, encoding the human sodium iodide symporter (hNIS. METHODS GLV-1h153(More)
Introduction A Meckel’s diverticulum (MD) is the most common congenital anomaly of the gastro-intestinal tract, and can present diagnostic and surgical challenges. Arising from failure of the omphalomesenteric duct to close properly, MD can occur in up to 2% of the population and can manifest as obscure gastrointestinal bleeding, Meckel’s diverticulitis,(More)
BACKGROUND Oncolytic herpes simplex virus-1 (HSV-1) is designed to specifically infect, replicate in, and lyse cancer cells. This study investigates a novel therapeutic regimen, combining the effects of NV1066 (a recombinant HSV-1) and hyperthermia in the treatment of pancreatic cancer. METHODS NV1066 is an attenuated HSV-1 that replicates in cells(More)
BACKGROUND The purpose of this study was to examine the relationship between magnetic resonance imaging (MRI) and surgical treatment of invasive breast cancer (IBC). METHOD The IBC patients treated from January 2003-June 2008 were reviewed by a single institution. RESULTS A total of 814 patients were treated, out of which 562 (69%) underwent breast(More)
Disappearance of liver lesions during neoadjuvant chemotherapy is common and is the basis for the increasing number of patients suitable for potentially curative hepatectomy in patients with hepatic colorectal metastases. Many of the liver lesions disappearing on radiologic evaluation after successful chemotherapy for metastatic colorectal cancer are still(More)
BACKGROUND Reversible electroporation has long been used to transfer macromolecules into target cells in the laboratory by using an electric field to induce transient membrane permeability. Recently, the electric field has been modulated to produce permanent membrane permeability and cell death. This novel technique, irreversible electroporation (IRE), is(More)
BACKGROUND This study investigates surgical management of tumors arising from or involving the aorta and major arterial structures. METHODS A retrospective single institutional review was conducted of patients undergoing arterial resection for tumors involving the aorta or major arterial structures between January 1992 and May 2009 at a tertiary care(More)