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Bacteriophage lysins (Ply), or endolysins, are phage-encoded cell wall lytic enzymes which are synthesized late during virus multiplication and mediate the release of progeny virions. Bacteriophages of the pathogen Listeria monocytogenes encode endolysin enzymes which specifically hydrolyze the cross-linking peptide bridges in Listeria peptidoglycan. Ply118(More)
We have cloned, sequenced, and characterized the genes encoding the lytic system of the unique Staphylococcus aureus phage 187. The endolysin gene ply187 encodes a large cell wall-lytic enzyme (71.6 kDa). The catalytic site, responsible for the hydrolysis of staphylococcal peptidoglycan, was mapped to the N-terminal domain of the protein by the expression(More)
The lysis genes of the virulent Staphylococcus aureus bacteriophage Twort were cloned and their nucleotide sequences determined. The endolysin gene plyTW encodes a 53.3-kDa protein, whose catalytic site is located in the amino-terminal domain. An enzymatically active fragment (N-terminal 271 amino acids) was overexpressed in Escherichia coli and partially(More)
MathCoach ist eine webbasierte und interaktive Trainingsumgebung f ¨ ur Mathematik, die den Lernenden¨Ubungen und Experimente inklusive individueller Hilfestellungu nd Bewertung zur Ve rfügung stellt. Im Gegensatz zu anderen Syste-men, die einenähnlichen Ansatz verfolgen, die den Lernenden aber meist nur eine statische Sammlung vonA ufgaben zur Bearbeitung(More)
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