Susanne Birke

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The unwinding of supercoiled phi X174 RFI DNA induced by the tumorigenic (+) and non-tumorigenic (-) enantiomers of trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE) has been investigated by agarose slab-gel and ethidium titration tube gel electrophoresis. The differences in adduct conformations were verified by flow linear(More)
The steady-state kinetics of human erythrocyte glucose-6-phosphate dehydrogenase (D-glucose-6-phosphate: NADP+ 1-oxidoreductase, EC 1.1.1.49) dimers were studied by initial rate measurement. These experiments gave intersecting double-reciprocal plots suggesting a ternary complex mechanism with a Km for NADP and glucose 6-phosphate of 11 microM and 43(More)
The apparent persistence length of enzymatically linearized pIBI30 plasmid DNA molecules approximately 2300 bp long, as measured by a hydrodynamic linear flow dichroism method, is markedly decreased after covalent binding of the highly tumorigenic benzo[a]pyrene metabolite 7R,8S-dihydroxy-9S,10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene [(+)-anti-BPDE]. In(More)
RATIONALE AND OBJECTIVES To compare electron beam tomography (EBT) with MR imaging (MRI) for detection of restenosis after coronary angioplasty (PTCA). METHODS One hundred eighteen patients after PTCA were investigated. By EBT, 50 axial images were acquired (3-mm slice thickness, 120-160 mL radiographic contrast agent). MRI was performed using(More)
The infrared vibrational circular dichroism (VCD) spectral features of prototypical peptide secondary structures were reported previously by Yasui and Keiderling [Yasui, S.C., & Keiderling, T.A. (1986) Biopolymers 25, 5]. These results demonstrated that the "random coil" peptide conformation exhibits VCD signals which are approximately mirror-image features(More)
The rehabilitation of patients in older age is depended from physical, psychical and social activity. But the limited possibility of adaptation, the broad individual spreeding of the character, and the polymorbidity in the older age have to taken into consideration. Hence follow some peculiarities in the rehabilitation process. The main aim of(More)