Susanna Kumlien Georén

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Single-walled carbon nanotubes (SWCNT) trigger pronounced inflammation and fibrosis in the lungs of mice following administration via pharyngeal aspiration or inhalation. Human exposure to SWCNT in an occupational setting may occur in conjunction with infections and this could yield enhanced or suppressed responses to the offending agent. Here, we studied(More)
Busulphan and cyclophosphamide (Bu/CP) are widely used in preparative regimens for bone marrow transplantation. Many studies have shown a wide variation in busulphan pharmacokinetics. Moreover, higher rates of liver toxicity were reported in Bu/CP protocols than in a total body irradiation (TBI)-containing regimen. In the present paper we investigated the(More)
CONCLUSIONS Endogenous GC protects against allergic inflammatory responses in the airways. These effects are modulated by both peripheral blockade and inhibition of release. Individual response patterns to stress, i.e. corticosterone release and peripheral sensitivity, may influence both the central and peripheral levels of the allergic airway reaction in(More)
Toll-like receptor (TLR) 7 and TLR9 recognise microbial products of viral descent. Since viruses are a common trigger of asthma exacerbations these TLRs have emerged as interesting therapeutic targets. Even though their effects on allergic inflammation have been evaluated in several models their effects on established allergic airway inflammation remains to(More)
In the upper airway, the production of antimicrobial peptides (AMPs) protects against bacteria, viruses and fungi. Previous investigations have revealed downregulated expression of AMPs in different manifestations of allergic disease. In this study, we examined the expression of LL-37, Ribonuclease7 (RNase7) and Liver-expressed antimicrobial peptide 2(More)
CONCLUSION A very low dose of dexamethasone (DEX) was as equally as sufficient as a pharmacological dose to decrease eosinophil inflammation in airways and bone marrow. The timing of DEX treatment in relation to allergen challenge was strongly decisive for the outcome of the inflammatory response. OBJECTIVES We aimed to study compartmental allergic airway(More)
Results Human nasal epithelial cells were shown to take up dextran, which ended up in intracellular endosome-like structures. In addition, MHC class II and co-stimulatory molecules were found on human and mouse nasal epithelial cells. Functionally, nasal epithelial cells from ovalbumin-sensitized mice activated and induced antigen-specific proliferation of(More)
Background Inflammation in the nasal mucosa has been shown to correlate with the development of CRSwNP (chronic rhinosinusitis with nasal polyps). The mechanism behind this is not fully understood but changes in the activity of the immune system might contribute to the growth of polyps. The present study focuses on the potential role of MHC II (major(More)
Background Dymista (MP29-02*) is a novel intranasal formulation of azelastine hydrochloride (AZE) and fluticasone propionate (FP) in an advanced delivery system with a welldocumented effect on allergic rhinitis. Its somewhat bitter taste is probably derived from AZE, a potent histamineH1-receptor antagonist. The taste is sometimes looked upon as a(More)
Background The airway epithelium constitutes the first line of defense in the protection against invading pathogens. It acts as a barrier, but it is also is a major source of early released inflammatory mediators, which help shape the inflammatory response. Neuropeptides, such as substance P (SP), have long been considered to be early contributors to the(More)
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