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Elucidation of the molecular mechanism and the efficacy in vivo of a novel 1,4-benzoquinone that inhibits 5-lipoxygenase.

• Anja Schaible, Rosanna Filosa, +15 authors Oliver Werz
• British journal of pharmacology
• 2014

BACKGROUND AND PURPOSE 1,4-Benzoquinones are well-known inhibitors of 5-lipoxygenase (5-LOX, the key enzyme in leukotriene biosynthesis), but the molecular mechanisms of 5-LOX inhibition are not… (More)

The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP).

• Carlo Pergola, Jana Gerstmeier, +10 authors Oliver Werz
• British journal of pharmacology
• 2014

BACKGROUND AND PURPOSE Leukotrienes (LTs) are inflammatory mediators produced via the 5-lipoxygenase (5-LOX) pathway and are linked to diverse disorders, including asthma, allergic rhinitis and… (More)

Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.

• E Karg, Susann Luderer, +6 authors Oliver Werz
• Journal of medicinal chemistry
• 2009

Pharmacological suppression of leukotriene biosynthesis by inhibitors of 5-lipoxygenase (5-LO) is a strategy to intervene with inflammatory and allergic disorders. We recently presented… (More)

Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX.

• Mahmoud Elkady, Raimund Niess, +5 authors Stefan A Laufer
• Journal of medicinal chemistry
• 2012

mPGES-1 is a promising target for development of new anti-inflammatory drugs. We aimed to create mPGES-1 inhibitors by modifying the structure of NSAIDs by replacing the carboxylic acid functionality… (More)

Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP).

• Erden Banoğlu, Burcu Çalişkan, +8 authors Oliver Werz
• Bioorganic & medicinal chemistry
• 2012

Pharmacological suppression of leukotriene biosynthesis by 5-lipoxygenase (5-LO)-activating protein (FLAP) inhibitors is a promising strategy to intervene with inflammatory, allergic and… (More)

Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils.

• Burcu Çalışkan, Susann Luderer, Yağmur Özkan, Oliver Werz, Erden Banoğlu
• European journal of medicinal chemistry
• 2011

We recently presented that compounds 4a-b moderately inhibited leukotriene (LT) formation in human neutrophils. For structural derivatization of 4a-b, novel thirty-six title compounds were… (More)

Cinnamyl-3,4-dihydroxy-α-cyanocinnamate is a potent inhibitor of 5-lipoxygenase.

• Carlo Pergola, Bianca Jazzar, +6 authors Oliver Werz
• The Journal of pharmacology and experimental…
• 2011

Lipoxygenases (LOs) are iron-containing enzymes that catalyze the conversion of arachidonic acid into hydroperoxyeicosatetraenoic acids (HPETEs) and other bioactive lipid mediators. In mammals, 5-LO,… (More)

Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase.

• Rosanna Filosa, Antonella Peduto, +8 authors Oliver Werz
• European journal of medicinal chemistry
• 2013

5-Lipoxygenase (5-LO), an enzyme that catalyzes the initial steps in the biosynthesis of pro-inflammatory leukotrienes, is an attractive drug target for the pharmacotherapy of inflammatory and… (More)

A dialysis patient with a life-threatening hyperkalaemia due to the use of a low-salt spread.

• M. (Marieke) C. van der Steen, Susann Luderer, Bart Veltman
• The Netherlands journal of medicine
• 2012

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