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Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled, phase 2 trial
TLDR
BNT162b2 given as a second dose in individuals prime vaccinated with ChAdOx1-S induced a robust immune response, with an acceptable and manageable reactogenicity profile. Expand
Paraoxonase activities in human follicular fluid: role in follicular maturation.
TLDR
An increase in the activities of PONs with follicle size is shown, thus providing indirect evidence for the role of Pons in follicle maturation. Expand
Lower follicular n-3 polyunsaturated fatty acid levels are associated with a better response to ovarian stimulation
TLDR
Results indicate that lower n-3 PUFA levels in large follicles, which are associated with younger women, predict a better response to ovarian stimulation based on the recovery of total and mature oocytes, total and top-quality embryos, and fertilization rate per cycle. Expand
Influence of oxygen partial pressure on the characteristics of human hepatocarcinoma cells
TLDR
Results suggest that the long-term culturing of human hepatoma cells at a low, more physiological pO2 induces antioxidant adaptations that could be mediated by p53, and may alter the cellular response to a subsequent oxidant challenge. Expand
Analysis of Protein Oxidative Modifications in Follicular Fluid from Fertile Women: Natural Versus Stimulated Cycles
TLDR
Findings from this work suggest that natural cycles are more protected against protein glycoxidation, and are the basis for further research to elucidate the possible relevance of this follicular biomarker of advanced glycation end product in fertility programs. Expand
Ovarian stimulated cycles reduce protection of follicular fluid against free radicals.
TLDR
It is suggested that COH could lead to premature ovarian aging and provide new insights into the possible prevention of the adverse effects of ovarian hyperstimulation by directing therapeutic applications to the maintenance of the redox balance and fatty acid status, with special attention to paraoxonase proteins and docosahexaenoic acid. Expand
Characterization of the paraoxonase system in follicular fluid of women subjected to an ovarian stimulation cycle.
TLDR
Results indicate that follicular fluid presents paraoxonase activities which are detectable by the methods developed in this study, suggesting that the PON system plays a role in oocyte maturation. Expand
Glutathione S-transferase activity in follicular fluid from women undergoing ovarian stimulation: role in maturation.
TLDR
Investigation of the involvement of GST in follicular maturation suggests that GST may play a role in the follicle maturation by detoxifying xenobiotics, thus contributing to the normal development of the oocyte. Expand
Antioxidant status of human follicular fluid: natural versus controlled ovarian hyper-stimulated cycles
Controlled ovarian hyperstimulation (COH) is used in standard protocols in in vitro fertilization (IVF). However, its use is associated with clinical complications such as ovarian hyperstimulationExpand