Susana Beceiro

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OBJECTIVE Activation of inflammatory pathways plays a critical role in the development of abdominal aortic aneurysms (AAA). Notch1 signaling is a significant regulator of the inflammatory response; however, its role in AAA is unknown. METHODS AND RESULTS In an angiotensin II-induced mouse model of AAA, activation of Notch1 signaling was observed in the(More)
Recent evidence suggests antimicrobial peptides protect the urinary tract from infection. Ribonuclease 7 (RNase 7), a member of the RNase A superfamily, is a potent epithelial-derived protein that maintains human urinary tract sterility. RNase 7 expression is restricted to primates, limiting evaluation of its antimicrobial activity in vivo. Here we(More)
Calcium signaling in phagocytes is essential for cellular activation, migration, and the potential resolution of infection or inflammation. The generation of reactive oxygen species (ROS) via activation of NADPH (nicotinamide adenine dinucleotide phosphate)-oxidase activity in macrophages has been linked to altered intracellular calcium concentrations.(More)
Neutrons constitute a major component in the radiation fi eld outside the shielding of particle accelerators. Consequently appropriate neutron dose meters are needed to survey the radiation levels. A thermoluminescence based neutron dosemeter is used at the UNILAC as well as at the SIS. It has been modifi ed to improve the response for high energetic(More)
The very neutron-rich oxygen isotopes 25 O and 26 O are investigated experimentally and theoretically. The unbound states are populated in an experiment performed at the R3B-LAND setup at GSI via proton-knockout reactions from 26 F and 27 F at relativistic energies around 442 and 414 MeV/nucleon, respectively. From the kinematically complete measurement of(More)
Experiments were performed in Cave C of GSI (Gesellschaft für Schwerionenforschung) using the LAND (Large Area Neutron Detector) in combination with the deflection magnet ALADIN (A LArge DIpol magNet) in front of the LAND where charged particles and neutrons can be separated. This arrangement is used to create high-energetic neutron fields by irradiation of(More)
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