Susan Weinstein

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The amyloidogenic peptide beta-amyloid has previously been shown to bind to neurons in the form of fibrillar clusters on the cell surface, which induces neurodegeneration and activates a program of cell death characteristic of apoptosis. To further investigate the mechanism of Abeta neurotoxicity, we synthesized the all-D- and all-L-stereoisomers of the(More)
Breast ultrasound (US) in conjunction with digital mammography has come to be regarded as the gold standard for breast cancer diagnosis. While breast US has certain advantages over digital mammography, it suffers from image artifacts such as posterior acoustic shadowing (PAS), presence of which often obfuscates lesion margins. Since classification of(More)
In this paper we propose an atlas-aided probabilistic model-based segmentation method for estimating the fibroglandular tissue in breast MRI, where a novel fibroglandular tissue atlas is learned to aid the segmentation. The atlas represents a pixel-wise likelihood of being fibroglandular tissue in the breast, which is derived by combining deformable image(More)
Bacterial lipopolysaccharide (LPS) elicits responses by macrophages that help the body repel infections. Recent evidence indicates that phosphatidylinositol 3-kinase (PI 3-kinase) may mediate some of these responses. Here, we show that exposing macrophages to LPS rapidly increased membrane-associated PI 3-kinase activity and also elevated p70 S6 kinase(More)
To the Editor: Eastern equine encephalitis virus (EEEV) is an arbovirus (family Togaviridae, genus Alpha-virus) transmitted to humans primarily from Aedes, Coquil-lettidia, and Culex mosquitoes. EEEV is maintained in a transmission cycle between Culiseta melanura mosquitoes and birds in freshwater hardwood swamps (1). Affected humans and horses are(More)
Volume 31 A volume in the At the Interface project 'Creative Engagements' Introduction On the morning of July 14th, 2005; a group of international philosophers, teachers, educational professionals, and educational specialists gathered at Mansfield College in Oxford, England for a conference entitled " Creative Engagements: Thinking with Children ". Many of(More)
Different brain pathways have been shown to subserve the therapeutic effects of neuroleptics and their extrapyramidal side effects. Agents which can discriminate between these pathways, therefore, might be able to produce 'atypical' clinical effects. Molindone, a novel neuroleptic of the indoleamine class, has been shown in basic paradigms to discriminate(More)
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