Susan Van Cleave

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Children with hypoactive semicircular canals commonly have delayed motor development. We studied ferrets whose vestibular labyrinths were removed at postnatal day 10 (P10) to evaluate 1) development of motor behavior, 2) soleus contractile characteristics, 3) muscle fiber diameter, and 4) the expression of myosin heavy chain (MHC) isoforms. At P30(More)
8E5 is a chronically human immunodeficiency virus (HIV)-infected human T cell line, which we have previously shown to be extremely susceptible to hydrogen peroxide (H2O2)-induced apoptosis due to a HIV-associated catalase deficiency. Here we report that HIV gene expression additionally renders 8E5 cells 10-fold more sensitive than either uninfected A3.01(More)
Stearic acid is toxic for T lymphocytes in vitro but has little effect on B lymphocytes. To investigate the molecular basis for this difference, purified murine T and B lymphocytes were compared for their abilities to incorporate and metabolize stearic acid. Unstimulated T and B cells incorporated identical amounts of stearic acid into six different(More)
Children with hearing deficits and hypofunctioning vestibular receptors frequently have delayed motor development. This study focuses on when the vestibular system needs to be active for normal motor behavior development and the maturation of the soleus muscle in the ferret. Both vestibular labyrinths were removed from ferrets at Postnatal day 10 (P10),(More)
The vestibular system is essential to the coordination of eye movements during head movements. Exercise, such as the eye movements mediated by the vestibular system, is a major factor in the development of muscle fiber types and the strength of muscle. In this study, the contents of the inner ear were removed (labyrinthectomy) from (LAB) ferrets at(More)
A3.01 is a human T cell line previously shown to be defective in cholesterol biosynthesis. Following passage into serum-free medium, A3.01 cells displayed a gradual decline in growth rate which correlated with a depletion of cellular cholesterol content and an accumulation of lanosterol and 24,25-dihydrolanosterol. At the point when cholesterol became(More)
Chronic exposure of BW5147 cells to arachidonic acid results in a complete inhibition of stearoyl-CoA desaturase 2 gene expression. Following removal of the fatty acid, gene transcription increased with a kinetic profile similar to the observed increases in both stearoyl-CoA desaturase 2 mRNA and unsaturated fatty acid synthesis. During the time period when(More)
1. Studies were performed to determine if the inability of murine T cells to provide primary helper function at low temperature (27 degrees C) could be correlated with their inability to synthesize unsaturated fatty acids (UFAs). 2. In the absence of exogenous oleic acid (18:1), splenocytes responded to a T-dependent (TD) Ag (trinitrophenyl-keyhole limpet(More)
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