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The use of chronic intravenous cannulae implanted in the jugular vein of mice utilizing techniques previously developed for larger rodents is discussed. Two cannula designs and a chronic infusion chamber are illustrated. Cannula insertion depths for mice of three strains and various body weights, and estimates of operative mortality and cannula durability(More)
The are numerous supersensitivity-like changes in the central nervous system associated with denervation and disuse. There is little evidence, however, for increases in postjunctional sensitivity exactly parallel to that which occurs in disused effector organs. As we learn more about the mechanisms responsible for supersensitivity in effector organs, it(More)