Susan Shahin

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1. Nitric oxide (NO) synthase inhibitors and Paf antagonists abrogate hypotension in septic shock. The latter may act by blocking intracellular transduction mechanisms in vascular smooth muscle cells and inflammatory cells. We examined the effect of Paf antagonists on expression of inducible NO synthase. 2. A murine macrophage cell line (J774.2) and rat(More)
In two studies (1982 and 1985/86), the presence of enterotoxigenic E. coli (ETEC) and other enteropathogenic bacteria was investigated in 779 stool specimens from children and adults with and without diarrhoeal disease. ETEC was isolated from 2% of diseased children and 1.6% of adult patients, but also from 0.5% of asymptomatic persons. Mixed infections(More)
A monoclonal antibody against the slow isoform of chicken skeletal muscle Ca2+-ATPase recognises, in nervous tissue, analogous membrane proteins which are most concentrated in the microsomal fraction. Histochemically, the immunoreactivity of the antibody is restricted to neurones where the staining is most intense in cell bodies and dendrites, weak in axons(More)
We have established that the monoclonal antibody (MAb) AA21, raised against a crude sarcolemmal fraction prepared from adult chicken anterior latissimus dorsi muscle, recognizes the slow twitch/cardiac isoform of calcium ATPase. This was done using a combination of immunohistochemistry at the light and electron microscopic level, the change in the cell(More)
Development of prophylactic vaccines against infectious diseases (such as malaria, tuberculosis and HIV) has been hindered by the lack of effective immunisation strategies that induce the cellular arm of the immune system necessary for protection against these intracellular pathogens. DNA vaccines, recombinant proteins and recombinant viral vectors are all(More)
We investigated the Thy-1-like immunoreactivity during the development of chicken skeletal muscle using a group of monoclonal antibodies raised and characterised against purified chicken brain Thy-1. The immunoreactivity attributable to bona fide Thy-1 in muscle was present in nerves, connective tissue associated with the intrafusal capsule and blood(More)
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