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Mitogen-activated protein kinase pathway-dependent tumor-specific survival signaling in melanoma cells through inactivation of the proapoptotic protein bad.
Mitogen-activated protein kinase (MAPK) signaling regulates fundamental cellular functions including proliferation, differentiation, and survival. We have demonstrated previously that inhibiting MAPKExpand
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WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells
We examined the role of the actin nucleation promoters neural Wiskott-Aldrich syndrome protein (N-WASP) and WAVE2 in cell protrusion in response to epidermal growth factor (EGF), a key regulator inExpand
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The Basic Region of the Diaphanous-autoregulatory Domain (DAD) Is Required for Autoregulatory Interactions with the Diaphanous-related Formin Inhibitory Domain*
Mammalian diaphanous-related (mDia) formins act as Rho GTPase effectors during cytoskeletal remodeling. Rho binding to mDia amino-terminal GTPase-binding domains (GBDs) causes the adjacentExpand
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Dia-Interacting Protein Modulates Formin-Mediated Actin Assembly at the Cell Cortex
BACKGROUND Mammalian Diaphanous (mDia)-related formins and the N-WASP-activated Arp2/3 complex initiate the assembly of filamentous actin. Dia-interacting protein (DIP) binds via its amino-terminalExpand
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T Cell Responses in Mammalian Diaphanous-related Formin mDia1 Knock-out Mice*
Activated T cells rapidly assemble filamentous (F-) actin networks in response to ligation of the T cell receptor or upon interaction with adhesive stimuli in order to facilitate cell migration andExpand
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Myeloproliferative defects following targeting of the Drf1 gene encoding the mammalian diaphanous related formin mDia1.
Rho GTPase-effector mammalian diaphanous (mDia)-related formins assemble nonbranched actin filaments as part of cellular processes, including cell division, filopodia assembly, and intracellularExpand
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through Inactivation of the Proapoptotic Protein Bad Tumor-Specific Survival Signaling in Melanoma Cells Mitogen-Activated Protein Kinase Pathway-Dependent Updated Version
Mitogen-activated protein kinase (MAPK) signaling regulates fundamental cellular functions including proliferation, differentiation, and survival. We have demonstrated previously that inhibiting MAPKExpand
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Medicine,UniversityofToronto,MountSinaiHospital,SamuelLunenfeldandTorontoGeneralHospital ResearchInstitutes,Toronto,OntarioM5G1X5,Canada
Activated T cells rapidly assemble filamentous (F-) actin networksinresponsetoligationoftheTcellreceptororuponinteraction with adhesive stimuli in order to facilitate cell migration and the formationExpand