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BACKGROUND Leukocyte telomere length (LTL) is an emerging marker of biological age. Chronic inflammatory activity is commonly proposed as a promoter of biological aging in general, and of leukocyte telomere shortening in particular. In addition, senescent cells with critically short telomeres produce pro-inflammatory factors. However, in spite of the(More)
BACKGROUND Emerging evidence indicates an association between cognitive function and physical performance in late life. This study examines the relationship between cognitive function and subsequent gait speed decline among high-functioning older adults. METHODS Measures of global cognitive function (Modified Mini Mental State Examination [3MS]) and(More)
Several studies have reported that older black and Latino adults have lower cognitive function test scores than older white adults, but few have comprehensively examined reasons for score differences. This study evaluates whether differences in health and socioeconomic indicators, including literacy level, can explain differences in cognitive function test(More)
Telomere shortening is a marker of cellular aging and has been associated with risk of Alzheimer's disease. Few studies have determined if telomere length is associated with cognitive decline in non-demented elders. We prospectively studied 2734 non-demented elders (mean age: 74 years). We measured cognition with the Modified Mini-Mental State Exam (3MS)(More)
INTRODUCTION Sex steroid hormone levels decline with age and in some studies this decline has been linked with depressive symptoms. This study investigates the association between total testosterone, free testosterone, and DHEAS levels with depressive symptoms in a well-functioning elderly population. METHODS Data are from 2855 well-functioning elderly(More)
THE ASSOCIATION BETWEEN daytime sleep, nighttime sleep, and nocturnal awakenings is not well defined. In studies with objective measures of daytime and nighttime sleep, the relationship of napping and sleep vary. Most studies have examined the effect of napping on subsequent night's sleep, with some studies showing that napping has little impact on(More)
OBJECTIVE Weight change may be considered an effect of depression. In turn, depression may follow weight change. Deteriorations in health may mediate these associations. The objective was to examine reciprocal associations between depressed mood and weight change, and the potentially mediating role of deteriorations in health (interim hospitalizations and(More)
IMPORTANCE Depression has been identified as a risk factor for dementia. However, most studies have measured depressive symptoms at only one time point, and older adults may show different patterns of depressive symptoms over time. OBJECTIVE To investigate the association between trajectories of depressive symptoms and risk of dementia in older adults. (More)
OBJECTIVE The purpose of this study is to determine if anxiety is associated with mortality and if race moderates and depression mediates this relationship. METHOD Participants are 3,015 adults aged 70-79 years. RESULTS Anxiety symptoms were significant predictors of all-cause, cardiovascular, and noncardiovascular mortality among blacks but not whites.(More)
OBJECTIVES To better understand the potential impact of hearing impairment (HI) and hearing aid use on emotional vitality and mental health in older adults. METHOD We investigated the cross-sectional association of HI with emotional vitality in 1,903 adults aged 76-85 years in the Health ABC study adjusted for demographic and cardiovascular risk factors.(More)