Susan M. Love

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Previous investigations of the potential value of postoperative environmental enrichment in enhancing functional recovery in brain-lesioned rats have yielded contradictory results. The present study sought to resolve some of the contradictions by drawing a clear distinction between the contribution of environmental enrichment to the processes of(More)
Comparison of the effects of environmental enrichment (EC) and impoverishment (IC) on learning in the rat is hindered by difficulty in distinguishing, experimentally, EC/IC differences in learning capacity per se from differences in performance-related variables such as sensory or motor ability, activity and motivation. Experiments are described which(More)
Postoperative environmental enrichment in brain-lesioned rats has been found to enhance performance in tasks in which a range of sensory cues can be utilized but not in tasks in which information from one particular sensory modality is essential to goal attainment. This has generally been construed as evidence of a role for environmental enrichment in(More)
The intraductal approach is particularly appealing in the setting of ductal carcinoma in situ (DCIS), a preinvasive breast neoplasm that is thought to be entirely intraductal in its extent. Based on an emerging understanding of the anatomy of the ductal system as well as novel techniques to leverage the access accorded by the intra-ductal approach,(More)
Opportunities for the detection, prediction, and treatment of breast cancer exist at three biological levels: systemically via the blood, at the whole organ level, and within the individual ductal lobular structures of the breast. This review covers the evaluation of approaches targeted to the ductal lobular units, where breast cancer begins. Studies to(More)
Breast cancer is the most common cancer affecting women globally. This paper discusses the current progress in breast cancer in Western countries and focuses on important differences of this disease in low- and middle-income countries (LMCs). It introduces several arguments for applying caution before globalizing some of the US-adopted practices in the(More)
Thirty women with ductal carcinoma-in-situ (DCIS) diagnosed by minimally invasive biopsy techniques are being recruited for an IRB approved study testing the effects of neoadjuvant pegylated liposomal doxorubicin (Doxil) delivered through the affected duct on histology and imaging. Pre-procedure MRI and mammography are obtained on consenting women with a(More)
Intraductal approaches encompass procedures and technologies that are designed to access and interrogate the ductal-alveolar systems of the human breast, and include nipple aspiration, ductal lavage, random periareolar fine needle aspiration, and ductoscopy. These approaches are being used to collect and analyze fluids and cells to develop methods for(More)