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RNA interference (RNAi) is proving to be a robust and versatile technique for controlling gene expression in mammalian cells. To fully realize its potential in vivo, however, it may be necessary to introduce chemical modifications to optimize potency, stability, and pharmacokinetic properties. Here, we test the effects of chemical modifications on RNA(More)
Fatigue, a universally reported symptom, may be one of the most prevalent feelings of people suffering from physical or mental diseases. An understanding of the factors leading to fatigue in the caregiving population can contribute to better care and support of both the cancer patient and the caregiver. The purpose of this discussion is to investigate and(More)
AIM To provide a critical review of research literature on the health of grandparents raising grandchildren, and identify directions for future research. METHODS Approaches used to access the research studies for this review included a comprehensive search using relevant electronic databases and a thorough examination of the references in each published(More)
The objective of this study was to evaluate associations between bulk tank somatic cell count (BTSCC) and herd management practices using data collected in the National Animal Health Monitoring System Dairy 2002 study. Twenty-six percent and 17.8% of 1,013 operations reported a BTSCC < 200,000 cells/mL and > 400,000 cells/mL, respectively. Univariate(More)
This paper describes an educational innovation called the Longitudinal Elder Initiative (LEI), which was developed by a BSN program to improve students' knowledge about the health needs and nursing care of older adults. In the LEI, new nursing students are paired with older adults in the community and develop a relationship with them over the duration of(More)
PROBLEM Few studies have focused on grandparent-raised children with behavioral/ emotional problems. The present study examined the therapeutic progress of this population. METHODS Data from this descriptive, correlational study were obtained from records of 207 children who received treatment at a child treatment center. Instruments included the Progress(More)
A variety of studies demonstrate a clear linkage between the positive psychological capacities of employees and desirable workplace outcomes. However, to date, little empirical research exists which has examined this relationship. Given current and projected challenges in healthcare industry, the need for nurses who are committed to the mission of their(More)
A latent viral immune inflammatory response (LVIIR) model is presented which integrates factors that contribute to chronic multisymptom illness (CMI) in both the veteran and civilian populations. The LVIIR model for CMI results from an integration of clinical experience with a review of the literature in four distinct areas: (1) studies of idiopathic(More)