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Adult SVZ stem cells lie in a vascular niche: a quantitative analysis of niche cell-cell interactions.
There is an emerging understanding of the importance of the vascular system within stem cell niches. Here, we examine whether neural stem cells (NSCs) in the adult subventricular zone (SVZ) lie closeExpand
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Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells
Neural stem cells are reported to lie in a vascular niche, but there is no direct evidence for a functional relationship between the stem cells and blood vessel component cells. We show thatExpand
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Timing of CNS Cell Generation A Programmed Sequence of Neuron and Glial Cell Production from Isolated Murine Cortical Stem Cells
Multipotent stem cells that generate both neurons and glia are widespread components of the early neuroepithelium. During CNS development, neurogenesis largely precedes gliogenesis: how is thisExpand
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FGF2 Concentration Regulates the Generation of Neurons and Glia from Multipotent Cortical Stem Cells
The embryonic cerebral cortex contains a population of stem-like founder cells capable of generating large, mixed clones of neurons and glia in vitro. We report that the default state of earlyExpand
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Adult SVZ lineage cells home to and leave the vascular niche via differential responses to SDF1/CXCR4 signaling.
Neural progenitor cells (NPCs) in the adult subventricular zone (SVZ) are associated with ependymal and vasculature niches, which regulate stem cell self-renewal and differentiation. Activated Type BExpand
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Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures
Swelling of primary astrocyte cultures by exposing them to hypotonic media caused release of label after the cells had been allowed to accumulate 3H-L-glutamate, 3H-D-aspartate, or 3H-taurine.Expand
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Multipotent Stem Cells from the Mouse Basal Forebrain Contribute GABAergic Neurons and Oligodendrocytes to the Cerebral Cortex during Embryogenesis
During CNS development, cell migrations play an important role, adding to the cellular complexity of different regions. Earlier studies have shown a robust migration of cells from basal forebrainExpand
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Asymmetric Distribution of EGFR Receptor during Mitosis Generates Diverse CNS Progenitor Cells
It has been debated whether asymmetric distribution of cell surface receptors during mitosis could generate asymmetric cell divisions by yielding daughters with different environmental responsivenessExpand
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Intrinsic programs of patterned cell lineages in isolated vertebrate CNS ventricular zone cells.
Using long-term, time-lapse video-microscopy, we investigated how single progenitor cells isolated from the early embryonic cerebral cortex produce neurons and glia over time. Clones of 10 cells orExpand
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Automated Cell Lineage Construction: A Rapid Method to Analyze Clonal Development Established with Murine Neural Progenitor Cells
Understanding cell lineage relationships is fundamental to understanding development, and can shed light on disease etiology and progression. We present a method for automated tracking of lineages ofExpand
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