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Abstrad Treatment of HC1 1 mouse mammary epithelial cells with the lactogenic hormones dexamethasone, insulin, and proladin (DIP) leads to cellular differentiation and production of the milk protein 13-casein. The following experimental evidence suggests the involvement of protein kinase C (PKC) in DIP induced signal transdudion. Down-regulation of PKC by 1(More)
Activating mutations in the KRAS and BRAF genes, leading to hyperactivation of the RAS/RAF/MAPK oncogenic signaling cascade, are common in patients with colorectal cancer (CRC). While selective BRAF inhibitors are efficacious in BRAFmut melanoma, they have limited efficacy in BRAFmut CRC patients. In a RASmut background, selective BRAF inhibitors are(More)
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. ● Word count of the Main Text excluding references and figure legends: 6502. ● Total number of figures and tables: 5 figures and 1 table. ● Supplementary Data are uploaded, including 3 tables. Author manuscripts have been peer reviewed and accepted for(More)
Tissue damage and repair processes are important factors in renal tumor progression. To determine whether protein kinase C (PKC) is involved in these processes, we characterized PKC isozymes during rat kidney regeneration using 3 models: (a) diffuse cortical hyperplasia and hypertrophy induced by folic acid; (b) focal necrosis of the $3 segments induced by(More)
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to mdi-cate this fact. and alters the function of its substrate adducin, submitted for publication. Abstract Tumor promotion/progression is known to be due(More)
Asbestos and the phorbol ester tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA), increase c-los and c-jun mRNA levels and AP-1 DNA binding activity in rat pleural mesothelial (RPM) cells, a target cell of asbestos-induced mesothellomas (Because protein kinase C (PKC) is the Intracellular receptor of phorbol ester tumor promoters and asbestos Is a(More)
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