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SARS-CoV-2 infection of kidney organoids prevented with soluble human ACE2
Nature reviews | N e p h r o l o g y the current COviD-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2). This virus gains entry to host cells via ACE2, which isExpand
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Kidney cancer: Targeting metabolism in RCC
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Synthetic lethality between loss of CDK4/6 activity and VHL inactivation
Nature reviews | Nephrology Nearly all cases of clear cell renal cell carcinoma (ccrCC) are associated with inactivating mutations or hypermethylation of the von Hippel– Lindau tumour suppressor geneExpand
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Glomerular disease: Thrombospondin type-1 domain-containing 7A—a new player in membranous nephropathy
Glomerular disease: Thrombospondin type-1 domain-containing 7A—a new player in membranous nephropathy
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Acute kidney injury: Activated protein C protective in IRI
The anticoagulant serine protease activated protein C (aPC) provides nephroprotection against ischaemia– reperfusion injury (IRI) by maintaining stability of the cold-shock protein YB-1, according toExpand
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Podocyte biology: The podocyte adhesome
Loss of podocyte adhesion is a major contributing factor to the progression of glomerular disease; however, comprehensive understanding of the role of focal adhesions (FAs) in podocyte biology isExpand
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An encapsulated bacterial cocktail for the removal of nitrogenous metabolic waste
researchers encapsulated the bacteria into calcium alginate microspheres. They then coated the microspheres with a poly-dopamine film to exclude macromolecules while permitting entry ofExpand
Hypertension: Dendritic cells: linking oxidation and hypertension
The adaptive immune system has a role in the pathogenesis of hypertension, but the mechanisms leading to T cell activation in hypertension are unknown. New findings show that isoketalmodifiedExpand
Nephrocytes: a role in immunity
Peptidoglycans (PGNs) are pathogenassociated molecular patterns (PAMPs) that are shed by bacteria, including those of the microbiome, to stimulate an immune response. Uncontrolled immune stimulationExpand
Belimumab in lupus nephritis
Lupus nephritis is the most common cause of morbidity and mortality among patients with systemic lupus erythematosus (SLE). Despite advances in our understanding of the mechanisms underlying lupusExpand