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Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma.
TLDR
The lack of effect of omalizumab on methacholine responsiveness suggests that IgE or eosinophils may not be causally linked to airway hyperresponsiveness to Methacholine in mild to moderate asthma. Expand
Epithelial-mesenchymal communication in the pathogenesis of chronic asthma.
TLDR
The observation that structural changes in the airways in children at or before the onset of asthma occurs irrespective of inflammation might suggest that premodeling is required before Th-2 inflammatory responses can be sustained. Expand
Severe asthma in adults: what are the important questions?
TLDR
Ass statements according to the literature defining SRA are presented in order to address the important questions and improve the understanding of mechanisms, natural history, and prognosis. Expand
Diesel exhaust activates redox-sensitive transcription factors and kinases in human airways.
TLDR
Observations demonstrate that DE activates redox-sensitive transcription factors in vivo consistent with oxidative stress triggering the increased synthesis of proinflammatory cytokines. Expand
Epithelial-mesenchymal interactions in the pathogenesis of asthma.
TLDR
It is proposed that impaired epithelial repair cooperates with the TH2 environment to shift the set point for communication within the trophic unit and leads to myofibroblast activation, excessive matrix deposition, and production of mediators that propagate and amplify the remodeling responses throughout the airway wall. Expand
Effect of bronchoconstriction on airway remodeling in asthma.
TLDR
Bronchoconstriction without additional inflammation induces airway remodeling in patients with asthma, and these findings have potential implications for management. Expand
Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease.
TLDR
Gene set enrichment analysis showed that pathways involved in oxidant/antioxidant responses were among the most differentially expressed gene pathways in smoking individuals, with further differences seen in COPD. Expand
Nuclear factor-kappaB1 (p50) limits the inflammatory and fibrogenic responses to chronic injury.
TLDR
Experimental evidence is provided that the inappropriate expression of TNF-alpha by nfkappab1(-/-) cells is because of lack of a p50-dependent histone deacetylase 1 (HDAC1)-mediated repression of T NF-alpha gene transcription. Expand
Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium
TLDR
Exposure to DE caused enhanced EGFR expression and phosphorylation of the tyrosine residue (Tyr 1173) which is in accordance with the previously demonstrated activation of the JNK, AP-1, p38 MAPK and NFkB pathways and associated downstream signalling and cytokine production. Expand
Increased expression of p21(waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium.
TLDR
It is concluded that p21(waf) overexpression in asthma influences cell proliferation and survival, which may cause abnormal repair responses that contribute to airway inflammation and remodeling. Expand
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