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A series of 123 consecutive referred cases of lens dislocation in the dog were classified as primary (100), secondary (21) and congenital (two). Cases designated as primary lens luxation comprised only the terrier breeds or crossbreds and collectively appeared to represent a single clinical entity characterised by age of onset (mean four to five years),(More)
Increasing evidence suggests that antibiotic dosing in critically ill patients with acute kidney injury (AKI) often does not achieve pharmacodynamic goals, and the continued high mortality rate due to infectious causes appears to confirm these findings. Although there are compelling reasons why clinicians should use more aggressive antibiotic dosing,(More)
BACKGROUND Reduced mobility after stroke may cause a loss of muscle mass which may, in theory, contribute to disability. We investigated longitudinal changes in muscle strength, lean cross-sectional area and muscle mass in all limbs after acute stroke. METHODS We recruited 17 patients within 72 h of hospital admission and measured (a) hand grip strength,(More)
OBJECTIVE To determine the relationship between a measure of fatigue and 2 indices of physical fitness, lower limb extensor power (LLEP) and walking economy. DESIGN This was a cross-sectional study of patients with stroke. Fatigue was assessed by vitality (VIT) score of the Medical Outcomes Study 36-Item Short-Form Health Survey version 2 (SF-36v2). LLEP(More)
The outcomes for 2005 consecutive patients aged 50 years or over admitted to two orthopaedic centres with a hip fracture were prospectively studied. All the patients were followed up to 1 year from injury. The mean orthopaedic ward stay was shorter in Edinburgh in comparison to Peterborough (20 versus 10 days), but the total hospital stay was shorter in(More)
The induction of persistent protective levels of pathogen-specific antibody is an important goal of immunization against childhood infections. However, antibody persistence is poor after immunization in infancy versus later in life. Serogroup C meningococci (MenC) are an important cause of bacteraemia and meningitis in children. The use of(More)
Children who have siblings and/or who attend day care have higher rates of nasopharyngeal colonization with pneumococci than lone children do. Pneumococcal colonization is usually asymptomatic but is a prerequisite for invasive disease. We studied the effect of social mixing with other children on immunity to a pneumococcal vaccine. One hundred sixty(More)
BACKGROUND AND PURPOSE There is little information on how to best measure poststroke fatigue. Our aim was to identify which currently available fatigue scale is most valid, feasible, and reliable in stroke patients. METHODS Fatigue scales were identified by systematic search, and the 5 with the best face validity were identified by expert consensus.(More)
OBJECTIVES To determine the feasibility and effect of exercise training after stroke. DESIGN Randomized exploratory trial comparing exercise training (including progressive endurance and resistance training) with relaxation (attention control). SETTING Interventions were performed in a rehabilitation hospital. PARTICIPANTS Sixty-six independently(More)