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  • J. Andrew Williams, Ruth Hyland, +6 authors Simon E Ball
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 November 2004
  • Glucuronidation is a listed clearance mechanism for 1 in 10 of the top 200 prescribed drugs. The objective of this article is to encourage those studying ligand interactions withContinue Reading
  • Odette A. Fahmi, Susan I Hurst, +8 authors R Scott Obach
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 August 2009
  • Cytochrome P450 3A4 (CYP3A4) is the most important enzyme in drug metabolism and because it is the most frequent target for pharmacokinetic drug-drug interactions (DDIs) it is highly desirable to beContinue Reading
  • Theunis C. Goosen, Jonathan N. Bauman, +4 authors Cho-Ming Loi
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 August 2007
  • Gemfibrozil coadministration generally results in plasma statin area under the curve (AUC) increases, ranging from moderate (2- to 3-fold) with simvastatin, lovastatin, and pravastatin to mostContinue Reading
  • Jonathan N. Bauman, Theunis C. Goosen, +6 authors Jennifer A. Williams
  • Chemistry, Medicine
  • Drug metabolism and disposition: the biological…
  • 1 September 2005
  • The predominant metabolic pathway of gemcabene in humans is glucuronidation. The principal human UDP-glucuronosyltransferases (UGTs) involved in the glucuronidation of gemcabene were determined inContinue Reading