Susan H Gordon

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OBJECTIVE:Alosetron is indicated for women with chronic, severe diarrhea-predominant IBS (d-IBS) who have not responded adequately to conventional therapy. Constipation is the most common adverse event with alosetron treatment. Multiple dosing regimens were assessed in a randomized, double-blind, placebo-controlled study (S3B30040) to determine efficacy,(More)
Purpose: Dumping syndrome is one of the most common causes of morbidity after gastric surgery. An estimated 25–50% of operated patients have some manifestations of dumping symptoms. The hallmark feature of dumping syndrome is diarrhea, which occurs following a meal. As a class, 5HT3 receptor antagonists slow colonic transit resulting in decreasing stool(More)
Purpose: Lotronex is a potent and selective 5-HT3 receptor antagonist indicated in women for the treatment of diarrhea predominant IBS. Constipation is a common side effect of treatment with drugs in this class. In earlier trials, constipation was reported in 28% and 5% of Lotronex and placebo treated subjects, respectively. In these trials, laxative use(More)
state. The range of CE ratios was between $32818 and $113978/QALY. Conclusions: Screening of hepatitis C patients with cirrhosis for HCC with US and/or AFP levels is as cost-effective as other accepted screening protocols. Screening with US alone at 12-month intervals is the most cost-effective regimen, relative to no screening, while screening with US and(More)
Corn samples suspected of causing refusal-to-eat syndrome in dairy cattle were examined mycologically. Fusarium moniliforme (14 isolates) and F. proliferatum (12 isolates) were the predominant fungi present. These isolates were tested for mycotoxin production on rice at 25 degrees C. Each strain of F. moniliforme produced fumonisin B1 (FB1: 378-15,600 ppm)(More)
Nurses in a variety of clinical settings are often involved in educating and managing patients with irritable bowel syndrome, though their knowledge and perceptions of irritable bowel syndrome are not well known. A national survey was undertaken as a part of a larger study of patients and healthcare providers to determine nurses' knowledge of irritable(More)