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PURPOSE To examine parameters for monitoring renal cryosurgery and correlate with histopathologic necrosis in a porcine model. Parameters include: 1) tissue temperature, 2) distance of tissue from the cryosurgical probe insertion site, and 3) inclusion of tissue by the visible iceball. MATERIALS AND METHODS Following midline incision, 6 healthy kidneys(More)
Background: Cryosurgery of liver lesions is becoming increasingly accepted for the ablation of liver tumors. Attempts at laparoscopic cryosurgery have been very limited and often need to be converted to open laparotomy due to the complexity of the procedure. Methods: Seven domestic pigs were anesthetized, and 17 small (0.7 cm mean diameter) tumor mimicking(More)
RATIONALE AND OBJECTIVES We have recently developed an iodinated lipid-based contrast agent capable of residing in the blood pool for extended periods of time relative to conventional water-soluble contrast agents. The purpose of this study was to examine the effects of combining this new blood-pool agent (ITG-PEG) with a hepatocyte-selective agent (ITG-LE;(More)
PURPOSE To determine the safety and feasibility of percutaneous cryoablation with computed tomographic (CT) guidance in a pig liver model. MATERIALS AND METHODS Nine angiographic balloons (mean diameter, 9 mm) were placed in the livers of seven domestic pigs (mean weight, 30.0 kg +/- 14.0 [SD]) as tumor-mimicking lesions. By using ultrasonographic and CT(More)
OBJECTIVES To verify histologically whether cryosurgery of the kidney can be accomplished reproducibly without injuring adjacent structures, using a combination of ultrasound and laparoscopic guidance. MATERIALS AND METHODS Six kidneys from three domestic female farm pigs were utilized in the study. Under general anesthesia and after obtaining(More)
OBJECTIVE We compared color Doppler velocity sonography and color Doppler energy sonography for the diagnosis of spermatic cord torsion in a canine model and determined the degree of torsion necessary to acutely halt testicular blood flow. MATERIALS AND METHODS Spermatic cord torsion was created in five dogs by exposing and rotating the ipsilateral testis(More)
PURPOSE To determine the imaging characteristics of a new computed tomographic (CT) contrast material with both hepatocyte-selective and blood-pool components (iodinated triglyceride (ITG)-dual) versus standard iohexol. MATERIALS AND METHODS VX2 carcinoma was inoculated in seven rabbits. Animals underwent nonenhanced, iohexol-enhanced (600 mg of iodine(More)
PURPOSE To determine the accuracy of ultrasonography (US) for prediction of hepatic tissue necrosis after cryoablation in normal pig liver. MATERIALS AND METHODS Five normal pig livers were treated with cryoablation monitored with US. After a single freeze cycle at 50% flow capacity, the widest diameter of the cryolesion was identified and marked with(More)
BACKGROUND Cryosurgical ablation of malignant hepatic tumors is being increasingly used for definitive treatment of metastatic colorectal and primary hepatic tumors. The lack of tumor necrosis near vessels that results from inadequate freezing may contribute to local recurrence and thus limit the applications of this therapy. This study was designed to(More)