Susan E. Bromley

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More than 22 types of human papillomavirus (HPV) have been detected in genital tract squamous cell intraepithelial lesions. Seven of two hundred eighty-six (2.4%) genital tract tissues in which HPV DNA was detected by in situ hybridization contained two or more different HPV types. When analyzed by site, 5 of 204 (2.4%) of cervical intraepithelial lesions(More)
When fixed newt lampbrush chromosomes are treated with RNase to remove nascent transcripts and are then probed with radiolabeled single-stranded DNA in 0.1 x SSC, proteins associated with the majority of the lateral loops bind the probe nonspecifically. One or more common hnRNP proteins, several of which are known to bind single-stranded DNA, could be(More)
OBJECTIVE Case series and spontaneous reports of endometrial cancer have raised the question as to whether the use of tibolone (introduced into the UK in 1991) is associated with an increased risk of endometrial cancer. This study set out to evaluate whether tibolone use is associated with an increased risk of endometrial cancer. METHODS Age-adjusted(More)
We have investigated transcription of the histone gene cluster on lampbrush chromosomes of the newt Notophthalmus viridescens. Clusters of the five histone genes are separated by long tracts of a DNA repeat called satellite 1. Previous in situ hybridization results demonstrated the presence of histone gene coding regions, intergene spacers, and flanking(More)
OBJECTIVES To establish the risk of myocardial infarction (MI) in users of hormone replacement therapy (HRT) compared with non-users and to compare the risk between different HRT regimens. METHODS A population-based cohort and case-control study, and a case-control study nested within a cohort of HRT users, using the UK General Practice Research Database.(More)
OBJECTIVE To determine prevalence and patterns of hormone replacement therapy (HRT) utilisation in women in the UK. DESIGN Prospective observational study. SETTING UK general practice. POPULATION Women from general practices throughout the UK. METHODS The study period was 1 January 1992 to 31 December 1998. Age-specific prevalence was calculated for(More)
Many animal studies and studies on intermediate clinical endpoints have shown hormone replacement therapy (HRT) to be associated with both favourable and unfavourable cardiovascular effects. We reviewed the literature regarding HRT and the distinct endpoint of acute myocardial infarction (AMI) in peri- and postmenopausal women. Searches of the MEDLINE and(More)
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