Susan Britt

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Ascorbic acid is commonly used as an antioxidant to prevent the decomposition of ligands in neurotransmitter receptor studies, but may alter biological membranes by initiating lipid peroxidation in the presence of physiologic metal ions. The aim of the present study was to characterize the effect of ascorbic acid-induced lipid peroxidation on an applicable(More)
Pituitary adenoma in a rabbitA 44-mo-old, female, nulliparous New Zealand White Rabbit (Oryctolagus cuniculus) presented with bilaterally diffusely enlarged mammary glands with enlarged, discolored teats that exuded brown, mucoid discharge. The complete blood count and serum chemistry panels were within normal limits, bacteria were not isolated from a(More)
Human leukocytes have been useful in studying desensitization phenomena to beta-adrenergic agonists in a number of clinical conditions. For example, we have previously shown that oral terbutaline causes a time-dependent decrease in neutrophil (PMN) beta receptor number, using the beta antagonist ligand [3H]dihydroalprenolol (DHA), in conjunction with a(More)
Nitro and amino phenylpiperazines were synthesized to study the agonist and antagonist activities of the phenylpiperazines at the human platelet 5-hydroxytryptamine2 (5-HT2) receptor. Amplification of ADP-induced aggregation and binding competition experiments with [3H]ketanserin were used to evaluate receptor interactions in this system. All the(More)
A series of arylpiperazines was examined for structure-function relationships at the human platelet serotonin (5-HT) receptor. Amplification of ADP-induced aggregation was used to measure 5-HT receptor activation. The platelet serotonergic agonists 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), 5-HT and 5-methoxytryptamine (5-MeOT) and the antagonist(More)
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