Susan B. Garavaglia

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OBJECTIVES The objective of this project was to determine pharmacy cost savings and improvement in adherence based on a combinatorial pharmacogenomic test (CPGx ) in patients who had switched or added a new psychiatric medication after having failed monotherapy for their psychiatric disorder. RESEARCH DESIGN AND METHODS The prospective project compared 1(More)
BACKGROUND The Medicare Part D coverage gap has been associated with lower adherence and drug utilization and higher discontinuation. Because osteoporosis has a relatively high prevalence among Medicare-eligible postmenopausal women, we examined changes in utilization of osteoporosis medications during this coverage gap. OBJECTIVES The purpose of this(More)
IMPORTANCE Results from the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression (ENHANCE) trial, announced in January 2008, demonstrated that ezetimibe use lowered cholesterol levels but did not slow the progression of atherosclerosis. OBJECTIVE To examine the association of this announcement with national patterns of(More)
OBJECTIVE To investigate whether compliance during the first 2 years of statin therapy is associated with reduced hospitalization rates and direct medical costs during year 3. STUDY DESIGN An integrated pharmacy and medical claims database was used to identify adult patients with a new statin prescription between July 1, 2001, and June 30, 2002. The study(More)
The Tanimoto Coefficient Self-organizing Map (TCSOM) [Garavaglia, 19981 is combined with a data transformation that “smears” binary vectors with an exponential decay transformation according to a subjective assessment of how close in meaning adjacent vector elements are. The methodology is demonstrated using managed health care plan satisfaction survey data(More)
Variations of the self-organizing map (SOM) paradigm have been introduced that require fewer computational resources such as memory and processing cycles. The familiar SOM invented by T. Kohonen requires iterative selection of a winner node and updating of a neighborhood of nodes in proximity to the winning node. With an application containing thousands of(More)
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