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Phytochromes function as thermosensors in Arabidopsis
Combining heat and light responses Plants integrate a variety of environmental signals to regulate growth patterns. Legris et al. and Jung et al. analyzed how the quality of light is interpretedExpand
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Unified rational protein engineering with sequence-based deep representation learning
TLDR
We apply deep learning to unlabeled amino-acid sequences to distill the fundamental features of a protein into a statistical representation that is semantically rich and structurally, evolutionarily and biophysically grounded. Expand
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Pseudomonas syringae Type III Effector HopBB1 Promotes Host Transcriptional Repressor Degradation to Regulate Phytohormone Responses and Virulence.
Independently evolved pathogen effectors from three branches of life (ascomycete, eubacteria, and oomycete) converge onto the Arabidopsis TCP14 transcription factor to manipulate host defense.Expand
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The Evening Complex coordinates environmental and endogenous signals in Arabidopsis
Plants maximize their fitness by adjusting their growth and development in response to signals such as light and temperature. The circadian clock provides a mechanism for plants to anticipate eventsExpand
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Variable Suites of Non-effector Genes Are Co-regulated in the Type III Secretion Virulence Regulon across the Pseudomonas syringae Phylogeny
Pseudomonas syringae is a phylogenetically diverse species of Gram-negative bacterial plant pathogens responsible for crop diseases around the world. The HrpL sigma factor drives expression of theExpand
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Unified rational protein engineering with sequence-only deep representation learning
TLDR
We apply deep learning to unlabelled amino acid sequences to distill the fundamental features of a protein into a statistical representation that is semantically rich and structurally, evolutionarily, and biophysically grounded. Expand
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Superantigen-induced apoptotic death of tumor cells is mediated by cytotoxic lymphocytes, cytokines, and nitric oxide.
The bacterial superantigen staphylococcal enterotoxin A (SEA) is a potent inducer of CTL activity and cytokine production in vivo. Protein A (PA) of Staphylococcal aureus has been found to haveExpand
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The molecular basis of host specialization in bean pathovars of Pseudomonas syringae.
Biotrophic phytopathogens are typically limited to their adapted host range. In recent decades, investigations have teased apart the general molecular basis of intraspecific variation for innateExpand
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The G-Box Transcriptional Regulatory Code in Arabidopsis1[OPEN]
DNA-binding and gene expression data predict which bHLH or bZIP transcription factors are likely regulators of genes near perfect G-box (CACGTG) motifs. Plants have significantly more transcriptionExpand
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Learning Microbial Interaction Networks from Metagenomic Count Data
TLDR
We develop a Poisson-multivariate normal hierarchical model to learn direct interactions from the count-based output of standard metagenomics sequencing experiments. Expand
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