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Transcriptomic analysis of the hippocampus from six inbred strains of mice suggests a basis for sex‐specific susceptibility and severity of neurological disorders
Identifying sex differences in gene expression within the brain is critical for determining why multiple neurological and behavioral disorders differentially affect males and females. Several
Efficient Projection onto the Perfect Phylogeny Model
TLDR
This paper uses Moreau's decomposition for proximal operators, and a tree reduction scheme, to develop a new algorithm to compute a projection problem that assigns a fitness cost to phylogenetic trees.
An Examination of Dynamic Gene Expression Changes in the Mouse Brain During Pregnancy and the Postpartum Period
TLDR
This study serves as an atlas of gene expression changes in the maternal brain, with the results demonstrating that pregnancy, parturition, and postpartum maternal experience substantially impact diverse brain regions.
On the Complexity of the Weighted Fused Lasso
TLDR
It is proved that the number of segments in the solution path of the weighted fused lasso is <inline-formula><tex-math notation="LaTeX">$\mathcal {O}(n^2)$</tex-Math></inline- formula>, and that, for some instances, it is £Omega (n*2) .
mRNA profiling reveals significant transcriptional differences between a multipotent progenitor and its differentiated sister
TLDR
The transcriptional profiles of SGPs and hmcs are strikingly different, and the hmc-biased genes are enriched with those that encode synaptic transmission machinery, which strongly suggests that it has neuron-like signaling properties, as would be expected from a cell preparing for proliferative divisions.
The Drosophila Post-mating Response: Gene Expression and Behavioral Changes Reveal Perdurance and Variation in Cross-Tissue Interactions
TLDR
Together, these data reveal how gene expression and behavior in females are influenced by cross-tissue interactions, by examining the impact of mating, fertility, and genotype.
Analysis of cell-type-specific chromatin modifications and gene expression in Drosophila neurons that direct reproductive behavior
TLDR
Examining Drosophila melanogaster fru P1 neurons that underlie reproductive behaviors in both sexes finds substantial changes in chromatin modification profiles across development and fewer differences between males and females, and identifies cell-type-specific super-enhancer-containing genes.
Analysis of cell-type-specific chromatin modifications and gene expression in Drosophila neurons that direct reproductive behavior
TLDR
Drosophila melanogaster fru P1 neurons that underlie reproductive behaviors in both sexes are examined, revealing novel stage- and sex-differences in gene expression and chromatin modifications.
Exact inference under the perfect phylogeny model
TLDR
ExACT is a tool that can explore the space of all possible phylogenetic trees, and performs exact inference under the PPM with noisy data, and allows users to obtain not just the most-likely tree for some input data, but exact statistics about the distribution of trees that might explain the data.
On the Complexity of the Weighted Fussed Lasso
TLDR
It is proved that the number of segments in the solution path of the weighted fused lasso is O(n, and for some instances Ω(n), and a new, very simple, proof of the O( n) bound is given.