Suresh Sharma

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Rotenone, a potent specific inhibitor of mitochondrial complex-1, appears to reproduce the behavioral features of Parkinson's disease in rats. It destroys dopaminergic neurons selectively, causing deficiency of dopamine in striatum which leads to impaired motor functions. Oxidative stress generated as a result of mitochondrial dysfunction and metabolism of(More)
BACKGROUND Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population. We have shown previously that mice deficient in monocyte chemoattractant protein-1 (MCP1/CCL2) or its receptor (CCR2) develop the features of AMD in senescent mice, however, the human genetic evidence so far is contradictory. We hypothesized that(More)
A five-parameter distribution called Beta Generalized Weibull (BGW) distribution is introduced. Exponential are its sub models. The cumulative distribution function (cdf) and the probability density function (pdf) have been expressed as mixtures of the Generalized Weibull cdfs and pdfs. The kth order moment has been derived. The non-linear equations for(More)
The pharmacokinetics, urinary excretion and dosage regimen of cefotaxime after its single intravenous administration (10 mg.kg-1) was investigated in hepatic-dysfunctioned buffalo calves. Hepatic-dysfunction was induced by intramuscular administration of paracetamol (250 mg.kg-1 body weight on day 1, followed by two subsequent doses of 50 mg.kg-1 body(More)
BACKGROUND Vascular endothelial growth factor-A (VEGF-A) and chemokne ligand-2 (CCL2) levels have been examined in Amyotrophic Lateral Sclerosis (ALS) patients in Western countries. We measured these values in North Indian ALS patients, since these patients display considerably enhanced survival duration. METHODS Sporadic ALS patients were included on the(More)
It has been postulated that there is a link between age related degenerative diseases and cancer. The TNF-related apoptosis-inducing ligand (TRAIL) has been shown to selectively kill tumor cells by binding to pro-apoptotic and anti-apoptotic receptors. Our aim was to study the levels of anti-apoptotic receptor (DcR1) in age related macular degeneration(More)
BACKGROUND There is an overwhelming burden of cardiovascular disease, type 2 diabetes and chronic kidney disease among Indigenous Australians. In this high risk population, it is vital that we are able to measure accurately kidney function. Glomerular filtration rate is the best overall marker of kidney function. However, differences in body build and body(More)
AIM The aim of the study was to estimate the levels of superoxide dismutase1 (SOD1) in patients of age-related macular degeneration (AMD) and examine the role of oxidative stress, smoking, hypertension, and other factors involved in the pathogenesis of AMD. METHODS 115 AMD patients and 61 healthy controls were recruited for this study. Serum SOD1 levels(More)
The purpose of the study was to determine serum complement factor H (CFH) levels in patients of age related macular degeneration (AMD) and examine its association with CFH Y402H polymorphism. 115 AMD patients and 61 normal controls were recruited in this study. The single nucleotide polymorphism was assayed by real time PCR and serum CFH levels were(More)