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- Surajith N. Wanasundara, Michal J. Wesolowski, +5 authors Carl A. Wesolowski
- Nuclear medicine communications
- 2016

OBJECTIVES
Glomerular filtration rate can be measured as the plasma clearance (CL) of a glomerular filtration rate marker despite body fluid disturbances using numerous, prolonged time samples. We desire a simplified technique without compromised accuracy and precision.
MATERIALS AND METHODS
We compared CL values derived from two plasma concentration… (More)

- Michal J. Wesolowski, Gary R. Conrad, +4 authors Carl A. Wesolowski
- European Journal of Nuclear Medicine and…
- 2015

Commonly used methods for determining split renal function (SRF) from dynamic scintigraphic data require extrarenal background subtraction and additional correction for intrarenal vascular activity. The use of these additional regions of interest (ROIs) can produce inaccurate results and be challenging, e.g. if the heart is out of the camera field of view.… (More)

- Surajith N Wanasundara, Mark Thachuk
- Journal of the American Society for Mass…
- 2007

A series of calculations, varying from simple electrostatic to more detailed semi-empirical based molecular dynamics ones, were carried out on charged gas phase ions of the cytochrome c(') dimer. The energetics of differing charge states, charge partitionings, and charge configurations were examined in both the low and high charge regimes. As well,… (More)

- Surajith N Wanasundara, Mark Thachuk
- The journal of physical chemistry. A
- 2009

Free energies are calculated for the protonated cytochrome c' dimer ion in the gas phase as a function of the center of mass distance between the monomers. A number of different charge partitionings are examined as well as the behavior of the neutral complex. It is found that monomer unfolding competes with complex dissociation and that the relative… (More)

- Carl A Wesolowski, Michal J Wesolowski, Paul S Babyn, Surajith N Wanasundara
- PloS one
- 2016

We present a model that generalizes the apparent volume of distribution and half-life as functions of time following intravenous bolus injection. This generalized model defines a time varying apparent volume of drug distribution. The half-lives of drug remaining in the body vary in time and become longer as time elapses, eventually converging to the… (More)

- Surajith N. Wanasundara, Michal J. Wesolowski, +5 authors Carl A. Wesolowski
- Nuclear medicine communications
- 2015

OBJECTIVES
The aim of the study was to determine which of three two-parameter fitting functions (exponential, linear-log, and negative-power function of time) most accurately models early chromium-51-EDTA (51Cr-EDTA) plasma concentration data prior to 120 min in patients with cirrhosis and ascites and understand how these fitting functions affect the… (More)

- Surajith N Wanasundara, Vikram Krishnamurthy, Shin-Ho Chung
- The journal of physical chemistry. B
- 2011

Molecular dynamics simulations, combined with umbrella sampling, is used to study how gramicidin A (gA) dimers dissociate in the lipid bilayer. The potential of mean force and intermolecular potential energy are computed as functions of the distance between center of masses of the two gA monomers in two directions of separation: parallel to the bilayer… (More)

- Carl A Wesolowski, Surajith N Wanasundara, Michal J Wesolowski, Belkis Erbas, Paul S Babyn
- EJNMMI physics
- 2016

BACKGROUND
The convolution approach to thyroid time-activity curve (TAC) data fitting with a gamma distribution convolution (GDC) TAC model following bolus intravenous injection is presented and applied to 99mTc-MIBI data. The GDC model is a convolution of two gamma distribution functions that simultaneously models the distribution and washout kinetics of… (More)

- Surajith N Wanasundara, Raymond J Spiteri, Richard K Bowles
- The Journal of chemical physics
- 2014

Monte Carlo simulation is used to study the dynamical crossover from single file diffusion to normal diffusion in fluids confined to narrow channels. We show that the long time diffusion coefficients for a series of systems involving hard and soft interaction potentials can be described in terms of a hopping time that measures the time it takes for a… (More)

- Ala'a F Eftaiha, Surajith N Wanasundara, Matthew F Paige, Richard K Bowles
- The journal of physical chemistry. B
- 2016

Coarse-grained molecular dynamics simulations have been used to investigate the effect of dipalmitoylphosphatidylcholine (DPPC) tail group polarity on the structural and phase behavior of both single component and binary mixed monolayers using the MARTINI force field. Surface pressure-area isotherms of single component systems indicate that DPPC monolayers… (More)