Supakit Wongwiwatthananukit

Learn More
BACKGROUND Although most patients with hypercholesterolemia require life-long therapy with statins, these drugs are underused due to high costs. Every-other-day therapy could be one strategy to resolve this problem. OBJECTIVE To compare the efficacy and safety of rosuvastatin 10 mg administered every other day versus once daily. METHODS An 8 week,(More)
Four new sesquiterpene lactones, 8α-(2'Z-tigloyloxy)-hirsutinolide (1), 8α-(2'Z-tigloyloxy)-hirsutinolide-13-O-acetate (2), 8α-(4-hydroxytigloyloxy)-hirsutinolide (3), and 8α-hydroxy-13-O-tigloyl-hirsutinolide (4), along with seven known derivatives (5-11), three norisoprenoids (12-14), a flavonoid (15), and a linoleic acid derivative (16), were isolated(More)
BACKGROUND Vitamin D deficiency has been linked to many of the characteristics of metabolic syndrome, but whether supplementation with vitamin D2 would improve insulin sensitivity or metabolic risk factors is not known. AIM To investigate effects of vitamin D2 supplementation on insulin sensitivity and metabolic parameters in metabolic syndrome patients.(More)
Bioassay-guided fractionation of the hexane extract from the flowers of Vernonia cinerea (Asteraceae) led to the isolation of a new sesquiterpene lactone, 8α-hydroxyhirsutinolide (2), and a new naturally occurring derivative, 8α-hydroxyl-1-O-methylhirsutinolide (3), along with seven known compounds (1 and 4-9). The structures of the new compounds were(More)
BACKGROUND Previous studies have shown conflicting results on low-density lipoprotein cholesterol (LDL-C) reduction for comparable doses of pitavastatin and atorvastatin. OBJECTIVE To compare the efficacy of pitavastatin 1 mg once daily with that of atorvastatin 10 mg once daily on lipoprotein change, safety, and cost per percent LDL-C reduction. (More)
OBJECTIVE To compare second- and third-year pharmacy students' competence, attitudes, and self-confidence in providing diabetes care before and after completing a hand-on diabetes training program and to determine if the program had an impact on students' attitude and self-confidence based on their year in the curriculum. DESIGN The program included(More)
OBJECTIVE To present the concept of nicotine-replacement therapy (NRT) and the pharmacologic approaches, nonprescription and prescription, to smoking cessation. DATA SOURCES Current clinical literature. DATA SYNTHESIS NRT can be delivered through a number of different nicotine-containing dosage forms (e.g., gum, patch, nasal spray, oral inhaler). The(More)
Background Vitamin D deficiency is a common problem worldwide. Several studies have shown an association between vitamin D deficiency and the increased risk of metabolic syndrome. No previous study has compared the efficacy and safety of ergocalciferol at 40,000 versus 20,000 IU/week in patients with metabolic syndrome. Objective To evaluate the efficacy of(More)
We report that hirsutinolide series, 6, 7, 10, 11, 20, and 22, and the semisynthetic analogues, 30, 31, 33, and 36, inhibit constitutively active signal transducer and activator of transcription (Stat)3 and malignant glioma phenotype. A position 13 lipophilic ester group is required for activity. Molecular modeling and nuclear magnetic resonance structural(More)
This study developed, implemented, and evaluated the use of partial-credit scoring for the combinedresponse multiple-choice (CRMC) examination format utilized in an elective nonprescription drugs course. Behavioral objectives and CRMC questions were developed and classified according to the appropriate cognitive domain of Bloom’s Taxonomy of Educational(More)