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This Working Paper should not be reported as representing the views of the IMF. The views expressed in this Working Paper are those of the author(s) and do not necessarily represent those of the IMF or IMF policy. Working Papers describe research in progress by the author(s) and are published to elicit comments and to further debate. The existing literature(More)
PURPOSE LBH589 is a novel histone deacetylase inhibitor that inhibits proliferation and induces apoptosis in tumor cell lines. In this phase I study, LBH589 was administered i.v. as a 30-minute infusion on days 1 to 7 of a 21-day cycle. EXPERIMENTAL DESIGN Fifteen patients (median age, 63 years; range, 42-87 years) with acute myeloid leukemia (13(More)
The views expressed in this Working Paper are those of the author(s) and do not necessarily represent those of the IMF or IMF policy. Working Papers describe research in progress by the author(s) and are published to elicit comments and to further debate. This paper examines the importance of agglomeration economies and institutions vis-à-vis initial(More)
The knowledge acquisition bottleneck in the development of large knowledge based applications has not yet been resolved. One approach which has been advocated is the systematic use of Machine Learning (ML) techniques. However, ML technology poses difficulties to domain experts and knowledge engineers who are not familiar with it. This paper discusses(More)
PURPOSE Panobinostat is partly metabolized by CYP3A4 in vitro. This study evaluated the effect of a potent CYP3A inhibitor, ketoconazole, on the pharmacokinetics and safety of panobinostat. METHODS Patients received a single panobinostat oral dose on day 1, followed by 4 days wash-out period. On days 5-9, ketoconazole was administered. On day 8, a single(More)
The receptor tyrosine kinase AXL has emerged in recent years as an potential oncology target due to its over expression in several types of cancers coupled with its ability to promote tumor growth and metastasis. In order to identify small molecule inhibitors of AXL, we built a homology model of its catalytic domain to virtually screen and identify(More)
Multiple myeloma is a malignancy involving plasma cell proliferation within the bone marrow. Survival of patients diagnosed with myeloma has significantly improved in the last decade, following the approval of novel agents. Despite great strides achieved in the management of multiple myeloma, it is still considered an incurable disease as the majority of(More)
Plan: Anti-inflammatory evaluation of acid hydrazide derivatives. Prologue: Hydrazide derivatives of organic compounds forms a significant group of derivatives which exhibit an array of biological activities like anti-inflammatory, antibacterial, antifungal, anti-neoplastic, antiviral etc. In view of above facts, we hereby reported the anti-inflammatory(More)