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This Working Paper should not be reported as representing the views of the IMF. The views expressed in this Working Paper are those of the author(s) and do not necessarily represent those of the IMF or IMF policy. Working Papers describe research in progress by the author(s) and are published to elicit comments and to further debate. The existing literature(More)
The views expressed in this Working Paper are those of the author(s) and do not necessarily represent those of the IMF or IMF policy. Working Papers describe research in progress by the author(s) and are published to elicit comments and to further debate. This paper examines the importance of agglomeration economies and institutions vis-à-vis initial(More)
The knowledge acquisition bottleneck in the development of large knowledge based applications has not yet been resolved. One approach which has been advocated is the systematic use of Machine Learning (ML) techniques. However, ML technology poses difficulties to domain experts and knowledge engineers who are not familiar with it. This paper discusses(More)
PURPOSE Panobinostat is partly metabolized by CYP3A4 in vitro. This study evaluated the effect of a potent CYP3A inhibitor, ketoconazole, on the pharmacokinetics and safety of panobinostat. METHODS Patients received a single panobinostat oral dose on day 1, followed by 4 days wash-out period. On days 5-9, ketoconazole was administered. On day 8, a single(More)
Plan: Anti-inflammatory evaluation of acid hydrazide derivatives. Prologue: Hydrazide derivatives of organic compounds forms a significant group of derivatives which exhibit an array of biological activities like anti-inflammatory, antibacterial, antifungal, anti-neoplastic, antiviral etc. In view of above facts, we hereby reported the anti-inflammatory(More)
BACKGROUND Craniopharyngiomas constitute 2 to 4% of intracranial neoplasms. However, the purely intraventricular variety are rare. Their magnetic resonance imaging (MRI) characteristically shows an intact third ventricular floor, a patent suprasellar cistern, an intact pituitary stalk, and the absence of sellar abnormalities. METHODS Between 1994 and June(More)
Decision support systems (DSS) that are simple, spatial, flexible, non-deterministic and have a long track record of practical application in a policy environment have until recently been uncommon. There has been a rapid expansion in the development and description of both quantitative and soft system methods that can be applied to decision-making processes(More)
Diabetes mellitus is a potentially morbid condition with high prevalence worldwide thus being a major medical concern. Experimental induction of diabetes mellitus in animal models is essential for the advancement of our knowledge and understanding of the various aspects of its pathogenesis and ultimately finding new therapies and cure. Experimental diabetes(More)