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PURPOSE In North America, no effective therapy has been available for patients with progressive metastatic colorectal cancer after front-line treatment with irinotecan, bolus fluorouracil (FU), and leucovorin (IFL). PATIENTS AND METHODS Patients with metastatic colorectal cancer who progressed after IFL therapy were randomly assigned to bolus and(More)
based, companies increasingly derive revenue from the creation and sustenance of long-term relationships with their customers. In such an environment, marketing serves the purpose of maximizing customer lifetime value (CLV) and customer equity, which is the sum of the lifetime values of the company’s customers. This article reviews a number of implementable(More)
The chemical space covered by compounds involved in metabolic reactions was compared with that of a random dataset of purchasable compounds by chemoinformatics techniques. The comparison was based on 3D structure, 2D structure, or descriptors of global properties, by means of self-organizing maps, random forests, and classification trees. The overlap(More)
Highly discriminating adjacency-cum-distance based topochemical indices termed as superaugmented eccentric connectivity topochemical indices for quantitative structure-activity and structure-property relationships (QSAR/QSPR) have been conceptualized in the present study. These indices were found to exhibit high sensitivity towards the presence and relative(More)
The topological indices were used to encode the structureal features of cephalosporins. Both topostructural and topochemical versions of a distance based descriptor, three adjacency based descriptors and five distance-cum-adjacency based descriptors were calculated. The values of 18 indices for each cephalosporin in the dataset were computed using an(More)
As firms increasingly rely on online media to acquire consumers, marketing managers feel comfortable justifying higher online marketing spend by referring to online metrics such as click‐through rate (CTR) and cost per acquisition (CPA). However, these standard online advertising metrics are plagued with attribution problems and do not account for dynamics.(More)
PURPOSE The addition of oxaliplatin to fluorouracil (FU) and leucovorin (LV) improves the outcome of patients with colorectal cancer (CRC). This multicenter study evaluated FU/LV with or without oxaliplatin in patients with metastatic CRC after disease progression on sequential fluoropyrimidine and irinotecan. PATIENTS AND METHODS Two hundred fourteen(More)