Many important molecular events associated with implantation and development occur within the female reproductive tract, especially within the uterus endometrium, during pregnancy periods. The endometrium includes the mucosal lining of the uterus, which provides a suitable site for implantation and development of a fertilized egg and fetus. To date, the… (More)
BACKGROUND Cell panning of phage-displayed antibody library is a powerful tool for the development of therapeutic and imaging agents since disease-related cell surface proteins in native complex conformation can be directly targeted. Here, we employed a strategy taking advantage of an integrated vector system which allows rapid conversion of scFv-displaying… (More)
ii DEDICATION I would like to dedicate this thesis to four wonderful groups of people. First, to Deidra and Andrew – you always made sure to listen when I lectured on " the plight ". Your interest in my work is worth more to me than I could ever show. Second, to the driven and talented women in science, engineering, and the arts – you gave me the courage to… (More)
Seth, Utkarsh, "A virtual reality interface for the design of compliant mechanisms" (2009). Graduate Theses and Dissertations. Paper 11115.
Dual-specificity phosphatase 26 (DUSP26) has recently proved to be a promising therapeutical target for the treatment of human cancers. Here, we report the first example for a successful application of the structure-based virtual screening approach to identify nine novel inhibitors of DUSP26. These inhibitors are also screened for having desirable… (More)
RNase H (retroviral ribonuclease H) cleaves the phosphate backbone of the RNA template within an RNA/DNA hybrid to complete the synthesis of double-stranded viral DNA. In the present study we have determined the complete structure of the RNase H domain from XMRV (xenotropic murine leukaemia virus-related virus) RT (reverse transcriptase). The basic… (More)