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PURPOSE The aim of this study was to investigate the utility of apparent diffusion coefficient (ADC) for prediction and early detection of treatment response in head and neck squamous cell carcinomas (HNSCC). EXPERIMENTAL DESIGN Diffusion-weighted magnetic resonance imaging studies were performed on 40 patients with newly diagnosed HNSCC before, during,(More)
OBJECTIVE The objective of our study was to predict response to chemoradiation therapy in patients with head and neck squamous cell carcinoma (HNSCC) by combined use of diffusion-weighted imaging (DWI) and high-spatial-resolution, high-temporal-resolution dynamic contrast-enhanced MRI (DCE-MRI) parameters from primary tumors and metastatic nodes. SUBJECTS(More)
The correlation between signals acquired using electroencephalography (EEG) and fMRI was investigated in humans during visual stimulation. Evoked potential EEG and BOLD fMRI data were acquired independently under similar conditions from eight subjects during stimulation by a checkerboard flashed at frequencies ranging from 2-12 Hz. The results indicate(More)
BACKGROUND AND PURPOSE Tumor microenvironment, including blood flow and permeability, may provide crucial information regarding response to chemoradiation therapy. Thus, the objective of this study was to investigate the efficacy of pretreatment DCE-MR imaging for prediction of response to chemoradiation therapy in HNSCC. MATERIALS AND METHODS DCE-MR(More)
Diffusion tensor imaging (DTI) is highly sensitive in detecting brain structure and connectivity phenotypes in autism spectrum disorders (ASD). Since one of the core symptoms of ASD is reduced sociability (reduced tendency to seek social interaction), we hypothesized that DTI will be sensitive in detecting neural phenotypes that correlate with decreased(More)
The purpose of this study is to determine whether diffusion tensor imaging (DTI) metrics including tensor shape measures such as linear and planar anisotropy coefficients (CL and CP) can help differentiate glioblastomas from solitary brain metastases. Sixty-three patients with histopathologic diagnosis of glioblastomas (22 men, 16 women, mean age 58.4(More)
PURPOSE To determine whether histogram analysis of diffusion-tensor (DT) magnetic resonance (MR) imaging metrics, including tensor shape measurements, can help determine the grades and subtypes of meningiomas. MATERIALS AND METHODS The institutional review board approved this HIPAA-compliant study. Nine atypical, three anaplastic, and 39 typical(More)
RATIONALE AND OBJECTIVES The aim of this study was to assess the role of diffusion-weighted imaging in predicting progression-free survival in patients with head and neck squamous cell carcinoma (HNSCC) treated with induction chemotherapy. MATERIALS AND METHODS Eighteen patients with HNSCC underwent diffusion-weighted imaging studies prior to treatment(More)
RATIONALE AND OBJECTIVES Phosphorous magnetic resonance spectroscopy ((31)P MRS) has been used to evaluate and predict treatment response in squamous cell carcinoma of the head and neck (HNSCC). Several studies have also shown the potential of proton MRS ((1)H MRS) in assessing response in HNSCC. In view of the inherent limitations associated with(More)
Lactate is an important metabolite in normal and malignant tissues detectable by NMR spectroscopy; however, it has been difficult to clinically detect the lactate methyl resonance because it is obscured by lipid resonances. The selective homonuclear multiple quantum coherence transfer technique offers a method for distinguishing lipid and lactate(More)