Sung-Young Hong

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Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized by relatively selective death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). 6-Hydroxydopamine (6-OHDA), a neurotoxin that causes the death of DA neurons, is commonly used to produce experimental PD model in rodents. Accumulating evidences suggest(More)
Galectin-3 is a member of the lectin subfamily that enables the specific binding of β-galactosides. It is expressed in a broad spectrum of species and organs, and is known to have various functions related to cell adhesion, signal transduction, and proinflammatory responses. Although, expression of galectin-3 in some activated neuroglia under(More)
Neuroinflammation is an early event and important contributor to the pathobiology of neurodegenerative diseases. Neuroglia, especially microglia, are a major central nervous system population that can modulate neuroinflammation. To determine potential key molecules in this process, we employed microarray analysis in the substantia nigra (SN) following(More)
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