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Cisplatin Cytotoxicity of Auditory Cells Requires Secretions of Proinflammatory Cytokines via Activation of ERK and NF-κB
The ototoxicity of cisplatin, a widely used chemotherapeutic agent, involves a number of mechanisms, including perturbation of redox status, increase in lipid peroxidation, and formation of DNAExpand
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Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzae
BackgroundDespite its direct connection to the nasopharynx which harbors otitis media pathogens as part of its normal flora, the middle ear cavity is kept free of these bacteria by as yet unknownExpand
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Expression of hepatocyte growth factor and c-Met in hypopharyngeal squamous cell carcinoma
Conclusion. Our results suggest that hepatocyte growth factor (HGF) may play an important role in the progression of hypopharyngeal cancer. Objective. HGF, a potent stimulator of hepatocyte growth,Expand
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Evidence that Cisplatin-induced Auditory Damage is Attenuated by Downregulation of Pro-inflammatory Cytokines Via Nrf2/HO-1
Recently, we demonstrated that pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6 played a critical role in cisplatin-induced cochlear injury and that flunarizine, known as a T-type Ca2+Expand
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Various causes and clinical characteristics in vertigo in children with normal eardrums.
OBJECTIVE The differential diagnosis of vertigo in children is extensive. Otitis media and middle ear effusion could be the most common causes of vertigo in children, but there are some problems inExpand
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Immortalization of Normal Adult Human Middle Ear Epithelial Cells Using a Retrovirus Containing the E6/E7 Genes of Human Papillomavirus Type 16
A human middle ear epithelial cell line (HMEEC-1) was established using human papillomavirus E6/E7 genes. HMEEC-1 has remained morphologically and phenotypically stable, even after 50 passages. TheExpand
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Functional Study of GJB2 in Hereditary Hearing Loss
Objectives/Hypothesis The gene GJB2 of the gap junction protein connexin 26 (Cx26) was found to be the main causative gene of autosomal recessive nonsyndromic hearing loss (DFNB1). Although 35delGExpand
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Spiral ligament fibrocytes release chemokines in response to otitis media pathogens
Conclusion. Spiral ligament fibrocytes (SLFs) may be involved in the innate immune response of the inner ear by producing chemoattractants for recruiting inflammatory cells such as neutrophils andExpand
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Nucleoplasm staining patterns and cell cycle-associated expression of Ki-67 in middle ear cholesteatoma.
OBJECTIVES To compare Ki-67 expression patterns in middle ear cholesteatoma with the corresponding retroauricular and external auditory canal skins, and to determine the cell cycle-dependentExpand
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3D micro-CT images of ossicles destroyed by middle ear cholesteatoma
Objective To reconstruct the 3D structures of normal ossicles and ossicles destroyed by different cholesteatomas, and to compare the volume fractions of the two types of ossicles. Material andExpand
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