Sung-Jun Park

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Resveratrol, a polyphenol in red wine, has been reported as a calorie restriction mimetic with potential antiaging and antidiabetogenic properties. It is widely consumed as a nutritional supplement, but its mechanism of action remains a mystery. Here, we report that the metabolic effects of resveratrol result from competitive inhibition of cAMP-degrading(More)
OBJECTIVE Resveratrol, a natural polyphenolic compound that is found in grapes and red wine, increases metabolic rate, insulin sensitivity, mitochondrial biogenesis, and physical endurance and reduces fat accumulation in mice. Although it is thought that resveratrol targets Sirt1, this is controversial because resveratrol also activates 5' AMP-activated(More)
Development of hepatocellular carcinoma (HCC) is a complex process involving multiple changes in gene expression and usually occurs in the presence of liver cirrhosis. In this research, we observed proteome alterations of three tissue types isolated from livers of HCC patients: normal, cirrhotic, and tumorous tissue. Proteome alterations were observed using(More)
The use of light for medical treatment has been studied previously. In this study, we examined the effect of light from a red light-emitting diode on osteogenic differentiation of mouse mesenchymal stem cells (D1 cells) which were cultured in the presence of osteogenic differentiation medium (ODM) for 3 days, then exposed to a red light-emitting diode (LED)(More)
STUDY DESIGN A retrospective radiographic analysis. OBJECTIVES To evaluate changes of upper thoracic curve and shoulder balance in thoracic adolescent idiopathic scoliosis patients treated by anterior selective thoracic fusion using video-assisted thoracoscopic surgery and to identify adequacy of earlier criteria of double thoracic (DT) curve for anterior(More)
This study investigated the changes of cerebral activation and lateralization due to the cognition of three driving speeds in comparison to a reference driving speed using functional magnetic resonance imaging fMRI. A driving video as a visual stimulation source was recorded with four different driving speeds in a real driving situation. The experiment(More)
This study investigated neuronal activation differences under two conditions: driving only and distracted driving. Driving and distraction tasks were performed using a Magnetic Resonance (MR)-compatible driving simulator with a driving wheel and pedal. The experiment consisted of three blocks, and each block had both a Rest phase (1 min) and a Driving phase(More)
The radiation stress induces cytotoxic responses of cell death as well as cytoprotective responses of cell survival. Understanding exact cellular mechanism and signal transduction pathways is important in improving cancer radiotherapy. Increasing evidence suggests that cyclic AMP response element binding protein (CREB)/activating transcription factor (ATF)(More)
Fig. 1. Effects of peptides on melanin synthesis. (A) a-MSH (1 mM) was added to increase the melanin synthesis of B16F10 melanoma cells and the effects of peptides were tested. Following 72 h of incubation, the cell pellet and supernatant were collected. Cell pellets of peptide treated cells were less pigmented than those of a-MSH treated cells. (B) The(More)