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Current genomic perspectives on animal diversity neglect two prominent phyla, the molluscs and annelids, that together account for nearly one-third of known marine species and are important both ecologically and as experimental systems in classical embryology. Here we describe the draft genomes of the owl limpet (Lottia gigantea), a marine polychaete(More)
The wnt gene family encodes a set of secreted glycoproteins involved in key developmental processes, including cell fate specification and regulation of posterior growth (Cadigan KM, Nusse R. 1997. Wnt signaling: a common theme in animal development. Genes Dev. 11:3286-3305.; Martin BL, Kimelman D. 2009. Wnt signaling and the evolution of embryonic(More)
The three-dimensional (3D) binary pharmacophore fingerprints find wide application as descriptors in applications ranging from virtual screening through library design. While the 3D content they capture is an intuitively attractive feature of such measures, maximizing their signal to noise ratio has proven to be a tricky balancing act. This issue surfaces(More)
The super-phylum Lophotrochozoa contains the plurality of extant animal phyla and exhibits a corresponding diversity of adult body plans. Moreover, in contrast to Ecdysozoa and Deuterostomia, most lophotrochozoans exhibit a conserved pattern of stereotyped early divisions called spiral cleavage. In particular, bilateral mesoderm in most lophotrochozoan(More)
This paper analyzes a dynamic lot-sizing problem for multiple products that are transported using common containers. Each production lot in a period is immediately shipped in the same period, the total freight cost is proportional to the number of containers used, and demand backlogging is not allowed. The objective of this study is to identify effective(More)
In sexually reproducing animals, primordial germ cells (PGCs) are often set aside early in embryogenesis, a strategy that minimizes the risk of genomic damage associated with replication and mitosis during the cell cycle. Here, we have used germ line markers (piwi, vasa, and nanos) and microinjected cell lineage tracers to show that PGC specification in the(More)
We propose a new heuristic for the single-searcher path-constrained discrete-time Markovian-target search. The algorithm minimizes an approximate, instead of exact, nondetection probability computed from the conditional probability that reflects the search history over the time windows of a fixed length, l. Having a pseudo-polynomial complexity, it can(More)
Coherent spin oscillations were nonthermally induced by circularly polarized pulses in the fully compensated antiferromagnet NiO. This effect is attributed to the action of the effective magnetic field generated by an inverse Faraday effect on the spins. The novelty of this mechanism is that spin oscillations are driven by the time derivative of the(More)