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Whether conventional gradient-echo (GE) blood oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) is able to map submillimeter-scale functional columns remains debatable mainly because of the spatially nonspecific large vessel contribution, poor sensitivity and reproducibility, and lack of independent evaluation. Furthermore, if(More)
Rat brain vasculature was imaged at 9.4T with blood oxygenation level-dependent (BOLD) microscopy. Data were acquired without exogenous contrast agent in <35 min using 3D gradient-echo imaging with 78-microm isotropic resolution. Detailed vascular patterns including intracortical veins and some branches were observed in simple magnitude-contrast data(More)
Balanced steady-state free precession (bSSFP) is an attractive fMRI method at high fields due to minimal spatial distortion. To examine sensitivity and specificity of bSSFP fMRI at ultrahigh magnetic field of 9.4T, we performed high-resolution pass-band high flip-angle (16°) bSSFP fMRI with four phase cycling (PC) angles at two repetition times (TR) of 10ms(More)
In this study, a new arterial spin labeling technique that requires no separate spin preparation pulse was developed. Sequential two-dimensional slices were acquired in ascending and descending orders by turns using balanced steady state free precession for pair-wise subtraction. Simulation studies showed this new technique, alternate ascending/descending(More)
An improved dual-echo sequence magnetic resonance (MR) imaging technique was developed to simultaneously acquire a time-of-flight MR angiogram (MRA) and a blood oxygenation level-dependent MR venogram (MRV) in a single MR acquisition at 3 T. MRA and MRV require conflicting scan conditions (e.g., excitation RF profile, flip angle, and spatial presaturation(More)
Alternate ascending/descending directional navigation (ALADDIN) is a new imaging technique that provides interslice perfusion-weighted and magnetization transfer (MT) asymmetry images. In this article, we investigated the effects of gradient imperfections on ALADDIN MT asymmetry (MTA) signals. Subtraction artifacts increasing with readout offsets were(More)
A new method for imaging magnetization transfer (MT) asymmetry with no separate saturation pulse is proposed in this article. MT effects were generated from sequential two-dimensional balanced steady-state free precession imaging, where interslice MT asymmetry was separated from interslice blood flow and magnetic field inhomogeneity with alternate(More)
We present a new method for magnetization transfer (MT) ratio imaging in the brain that requires no separate saturation pulse. Interslice MT effects that are inherent to multi-slice balanced steady-state free precession (bSSFP) imaging were controlled via an interslice delay time to generate MT-weighted (0 s delay) and reference images (5-8 s delay) for MT(More)
We implemented pseudo-continuous ASL (pCASL) with 2D and 3D balanced steady state free precession (bSSFP) readout for mapping blood flow in the human brain, retina, and kidney, free of distortion and signal dropout, which are typically observed in the most commonly used echo-planar imaging acquisition. High resolution functional brain imaging in the human(More)
Balanced steady-state free precession (bSSFP) is a highly efficient pulse sequence that is known to provide the highest signal-to-noise ratio per unit time. Recently, bSSFP is getting increasingly popular in both the research and clinical communities. This review will be focusing on the application of the bSSFP technique in the context of probing the(More)