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We propose a novel method, called heterogeneous clustering ensemble (HCE), to generate robust clustering results that combine multiple partitions (clusters) derived from various clustering algorithms. The proposed method combines partitions of various clustering algorithms by means of newly-proposed the selection and the crossover operation of the genetic(More)
In modern data mining applications, clustering algorithms are among the most important approaches, because these algorithms group elements in a dataset according to their similarities, and they do not require any class label information. In recent years, various methods for ensemble selection and clustering result combinations have been designed to optimize(More)
BACKGROUND/AIMS Epigallocatechin-3-gallate (EGCG), the primary catechin in green tea, has anti-inflammatory and anti-oxidative properties. The aim of the current study was to characterize the impact of EGCG on lipopolysaccharide (LPS)-induced innate signaling in bone marrow-derived macrophages (BMMs) isolated from ICR mice. METHODS The effect of EGCG on(More)
Purpose: Gastric cancer is heterogeneous clinically and histologically, and prognosis prediction by tumor grade or type is difficult. Although previous studies have suggested that frozen tissue ^ based molecular classifications effectively predict prognosis, prognostic classification on forma-lin-fixed tissue is needed, especially in early gastric cancer.(More)
The incidence of brain metastasis from hepatocellular carcinoma (HCC) is expected to increase as a result of prolonged survival due to the recent advances in HCC treatment. However, there is no definite treatment strategy for brain metastasis from HCC mainly due to its rarity and dismal prognosis. To provide helpful recommendations in treatment of brain(More)
BACKGROUND Black tea has been shown to elicit anti-oxidant, anti-carcinogenic, anti-inflammatory and anti-mutagenic properties. In this study, we investigated the impact of black tea extract (BTE) on lipopolysaccharide (LPS)-induced NF-κB signaling in bone marrow derived-macrophages (BMM) and determined the therapeutic efficacy of this extract on colon(More)
BACKGROUNDS Expression of Livin, a member of the inhibitors of apoptosis protein family, is associated with tumor development and progression. The aims of this study were to evaluate whether Livin affects oncogenic biological behavior of colorectal cancer cells, and to document the relationship between its expression and various clinicopathological(More)
BACKGROUND/AIMS Gastroesophageal reflux (GER) has been implicated in the pathogenesis of chronic cough. The aims of this study were to evaluate the diagnostic usefulness of multichannel intraluminal impedance combined with pH monitoring (MII/pH monitoring) in patients with suspected symptoms of gastroesophageal reflux disease (GERD) and to assess the(More)
The development of functional genomics including transcriptomics, proteomics and metabolomics allow us to monitor a large number of key cellular pathways simultaneously. Several technology-specific data models have been introduced for the representation of functional genomics experimental data, including the MicroArray Gene Expression-Object Model(More)